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Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients

BACKGROUND: Brucellosis is still endemic in many developing countries and frequently leads to misdiagnosis and treatment delays. Indirect inflammatory markers such as mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR...

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Autores principales: Tekin, Recep, Aktar, Fesih, Ayaz, Celal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631101/
http://dx.doi.org/10.1093/ofid/ofx163.844
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author Tekin, Recep
Aktar, Fesih
Ayaz, Celal
author_facet Tekin, Recep
Aktar, Fesih
Ayaz, Celal
author_sort Tekin, Recep
collection PubMed
description BACKGROUND: Brucellosis is still endemic in many developing countries and frequently leads to misdiagnosis and treatment delays. Indirect inflammatory markers such as mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate and compare the levels of these markers for prognostic purposes, and to assess the correlation of C-reactive protein (CRP) with brucellosis in adults and children. METHODS: The study included 137 adults and 141 age- and gender-matched healthy controls, as well 71 children and 81 age- and gender-matched healthy controls. Hematological parameters and CRP were retrospectively recorded and compared between the adult and pediatric patients. RESULTS: The mean age of the adult patients (54% female) was 43.1 ± 15.4 years, whereas the mean age of the pediatric patients (50.7% male) was 9.5 ± 3.6 years. Significantly higher lymphocyte count, and lower neutrophil count, platelet count, RDW, MPV, NLR and PLR values were found in adult brucellosis patients compared with their healthy subjects, whereas higher lymphocyte count, PDW and lower neutrophil count, platelet count, MPV, NLR and PLR values were observed in pediatric brucellosis patients compared with the control subjects. Significantly higher neutrophil count (p=0.019) and NLR (p<0.001) were found in adult patients compared with the pediatric patients. Positive correlation was found between CRP and NLR (R(2) = 0.052, P = 0.011), PLR (R(2) = 0.061, P = 0.006) in adult patients. CONCLUSION: Based on our findings, we consider that the use of complementary indirect markers such as MPV, NLR, PLR and RDW together with the CRP test – which is used concomitantly with serological diagnostic tests in situations where brucellosis is suspected – might be helpful in the diagnosis and follow-up of brucellosis, as well as in the evaluation of complications and response to therapy, in both adult and pediatric brucellosis patients. DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-56311012017-11-07 Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients Tekin, Recep Aktar, Fesih Ayaz, Celal Open Forum Infect Dis Abstracts BACKGROUND: Brucellosis is still endemic in many developing countries and frequently leads to misdiagnosis and treatment delays. Indirect inflammatory markers such as mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate and compare the levels of these markers for prognostic purposes, and to assess the correlation of C-reactive protein (CRP) with brucellosis in adults and children. METHODS: The study included 137 adults and 141 age- and gender-matched healthy controls, as well 71 children and 81 age- and gender-matched healthy controls. Hematological parameters and CRP were retrospectively recorded and compared between the adult and pediatric patients. RESULTS: The mean age of the adult patients (54% female) was 43.1 ± 15.4 years, whereas the mean age of the pediatric patients (50.7% male) was 9.5 ± 3.6 years. Significantly higher lymphocyte count, and lower neutrophil count, platelet count, RDW, MPV, NLR and PLR values were found in adult brucellosis patients compared with their healthy subjects, whereas higher lymphocyte count, PDW and lower neutrophil count, platelet count, MPV, NLR and PLR values were observed in pediatric brucellosis patients compared with the control subjects. Significantly higher neutrophil count (p=0.019) and NLR (p<0.001) were found in adult patients compared with the pediatric patients. Positive correlation was found between CRP and NLR (R(2) = 0.052, P = 0.011), PLR (R(2) = 0.061, P = 0.006) in adult patients. CONCLUSION: Based on our findings, we consider that the use of complementary indirect markers such as MPV, NLR, PLR and RDW together with the CRP test – which is used concomitantly with serological diagnostic tests in situations where brucellosis is suspected – might be helpful in the diagnosis and follow-up of brucellosis, as well as in the evaluation of complications and response to therapy, in both adult and pediatric brucellosis patients. DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2017-10-04 /pmc/articles/PMC5631101/ http://dx.doi.org/10.1093/ofid/ofx163.844 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Tekin, Recep
Aktar, Fesih
Ayaz, Celal
Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients
title Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients
title_full Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients
title_fullStr Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients
title_full_unstemmed Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients
title_short Comparison of Inflammatory Markers Between Adult and Pediatric Brucellosis Patients
title_sort comparison of inflammatory markers between adult and pediatric brucellosis patients
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631101/
http://dx.doi.org/10.1093/ofid/ofx163.844
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