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In Vivo Efficacy of Humanized Exposures of Cefiderocol Compared with Cefepime (FEP) and Meropenem (MEM) against Gram-negative Bacteria in a Murine Thigh Model

BACKGROUND: Cefiderocol (S-649266) is a novel siderophore cephalosporin under development by Shionogi (Osaka, Japan). Previous studies have demonstrated cefiderocol efficacy against a diverse population of Gram-negative bacteria with MICs ≤ 4 μg/mL. Our aim was to further define the agent’s clinical...

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Detalles Bibliográficos
Autores principales:	Monogue, Marguerite, Tsuji, Masakatsu, Yamano, Yoshinori, Echols, Roger, Nicolau, David P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631164/ http://dx.doi.org/10.1093/ofid/ofx163.1216

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