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Pharmacokinetic-Pharmacodynamic Target Attainment Analysis to Support VL-2397 Dose Selection for a Phase 2 Trial in Patients with Invasive Aspergillosis

BACKGROUND: VL-2397 is a novel antifungal agent in clinical development for treatment of invasive aspergillosis (IA). The analysis objectives were to: 1) develop a population PK model using data from a Phase 1 trial in healthy adult volunteers, 2) define the PK-PD driver of efficacy in a mouse model...

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Detalles Bibliográficos
Autores principales:	Rubino, Christopher M, Smith, Larry R, Mammen, Mammen P, Hopkins, Andrew M, Lakota, Elizabeth A, Sullivan, Sean M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631219/ http://dx.doi.org/10.1093/ofid/ofx163.1211

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