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Lack of Clinically Relevant Effect of Bictegravir (BIC, B) on Metformin (MET) Pharmacokinetics (PK) and Pharmacodynamics (PD)

BACKGROUND: BIC is a novel integrase inhibitor coformulated with emtricitabine (F) and tenofovir alafenamide (TAF) for treatment of HIV. MET is first-line therapy in diabetic HIV patients. In vitro, BIC inhibits renal transporters OCT2 and MATE1, which affect MET disposition. This study evaluated th...

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Detalles Bibliográficos
Autores principales:	Custodio, Joseph, West, Steve, Yu, Amanda, Martin, Hal, Graham, Hiba, Quirk, Erin, Kearney, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631370/ http://dx.doi.org/10.1093/ofid/ofx163.1082

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