Cap-dependent Endonuclease Inhibitor S-033188 for the Treatment of Influenza: Results from a Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study in Otherwise Healthy Adolescents and Adults with Seasonal Influenza

BACKGROUND: Cap-dependent endonuclease (CEN) resides in the PA subunit of influenza virus polymerase and mediates the “cap-snatching” process during viral mRNA biosynthesis. S-033188 is a potent, selective, small molecule inhibitor of CEN. Here we report clinical and virologic outcomes from a global...

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Detalles Bibliográficos
Autores principales: Portsmouth, Simon, Kawaguchi, Keiko, Arai, Masatsugu, Tsuchiya, Kenji, Uehara, Takeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
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Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631501/
http://dx.doi.org/10.1093/ofid/ofx180.001

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