The Detection Rates of Urogenital Chlamydia trachomatis and Neisseria gonorrhoeae in Chinese Population Applying for U.S. Immigration

BACKGROUND: Medical screening for gonorrhea is under the mandatory requirements of the Center for Disease Control and Prevention for aliens applying for U.S. immigration. Gonorrhea is frequently associated with Chlamydia trachomatis (CT) infection. There is limited data on the detection rates of urogenital CT and Neisseria gonorrhoeae (NG) in Chinese population. METHODS: Data on physical examinations of applicants in Guangdong International Travel Health Care Center, China were collected and retrospectively analyzed. The nucleic acids of urogenital CT and NG from urine specimens were detected by fluorescent probe PCR using cobas 4800 CT/NG Amplication Detection Kit (Roche Molecuar Systems, Inc.). The detection rates of CT and NG among the overall population were assessed. In addition, the detection rates of CT by age and gender were also evaluated. RESULTS: In total, 10,549 applicants underwent physical examinations from September 2016 to March 2017. Mean (SD) age was 41.4 (15.6) years, ranging from 15 to 90 years. The proportion of females (56.17%) was higher than that of males (43.83%). Of the 10,512 people who completed the detection of CT, 369 (3.51%) were CT-positive. The detection rate of CT was significantly higher in females (4.15%) than males (2.69%) (Table 1). The highest CT-positive rate was observed in the age group of 25–29 years (24/344, 6.98%) among males, while in a slightly younger age group of 20–24 years (34/524, 6.49%) among females (Figure 1). Of the 10,510 applicants who completed the detection of NG, 10 (0.10%) were NG positive. The detection rate of NG in males and females was 0.11 and 0.08%, respectively (Table 1). CONCLUSION: Our study first reported the detection rates of urogenital CT (3.51%) and NG (0.10%) among Chinese applicants for U.S. immigration. The highest positive rate of CT was observed among young and middle-aged people, which should gain more attention. DISCLOSURES: All authors: No reported disclosures.