Cargando…

Galidesivir, a Direct-Acting Antiviral Drug, Abrogates Viremia in Rhesus Macaques Challenged with Zika Virus

BACKGROUND: Zika virus (ZIKV) was first isolated from a sentinel rhesus monkey in 1947. ZIKV infection in humans is associated with serious neurological and reproductive complications. No antiviral or protective vaccine is yet available. Galidesivir an adenosine analog is a potent viral RNA-dependen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, So-Yon, Osuna, Christa, Lakritz, Jessica, Chen, Elsa, Yoon, Gyeol, Taylor, Ray, MacLennan, Steve, Leonard, Michael, Giuliano, Enzo, Mathis, Amanda, Berger, Elliot, Babu, Ys, Sheridan, William, Whitney, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631744/ http://dx.doi.org/10.1093/ofid/ofx162.129

Ejemplares similares

Efficacy of Galidesivir against Ebola Virus Disease in Rhesus Monkeys
por: Warren, Travis, et al.
Publicado: (2017)

Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques
por: Dudley, Dawn M., et al.
Publicado: (2022)

Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques
por: George, Jeffy, et al.
Publicado: (2017)

An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral
por: Julander, Justin G., et al.
Publicado: (2021)

Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters
por: Westover, Jonna B., et al.
Publicado: (2018)

Oropharyngeal mucosal transmission of Zika virus in rhesus macaques
por: Newman, Christina M., et al.
Publicado: (2017)

Activity of Galidesivir in a Hamster Model of SARS-CoV-2
por: Taylor, Ray, et al.
Publicado: (2021)

Neurocognitive impact of Zika virus infection in adult rhesus macaques
por: Hsu, Denise C., et al.
Publicado: (2022)

Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques
por: Pedreño-Lopez, Nuria, et al.
Publicado: (2021)

Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques
por: Coffey, Lark L., et al.
Publicado: (2017)

A rhesus macaque model of Asian-lineage Zika virus infection
por: Dudley, Dawn M., et al.
Publicado: (2016)

Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques
por: Aliota, Matthew T., et al.
Publicado: (2016)

Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques
por: McCracken, Michael K., et al.
Publicado: (2017)

Duration of Zika Viremia in Serum
por: Fontaine, Albin, et al.
Publicado: (2018)

Crossmodal Integration of Conspecific Vocalizations in Rhesus Macaques
por: Payne, Christa, et al.
Publicado: (2013)

Limited Impact of Passive Non-Neutralizing Antibody Immunization in Acute SIV Infection on Viremia Control in Rhesus Macaques
por: Nakane, Taku, et al.
Publicado: (2013)

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology
por: Hirsch, Alec J., et al.
Publicado: (2018)

Preliminary Studies on Immune Response and Viral Pathogenesis of Zika Virus in Rhesus Macaques
por: Woollard, Shawna M., et al.
Publicado: (2018)

Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
por: Hirsch, Alec J., et al.
Publicado: (2017)

Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques
por: Nguyen, Sydney M., et al.
Publicado: (2017)

Impact of prior Dengue immunity on Zika vaccine protection in rhesus macaques and mice
por: Larocca, Rafael A., et al.
Publicado: (2021)

Early Embryonic Loss Following Intravaginal Zika Virus Challenge in Rhesus Macaques
por: Newman, Christina M., et al.
Publicado: (2021)

Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus
por: Vang, Lo, et al.
Publicado: (2021)

Effect of Plasma Viremia on Apoptosis and Immunophenotype of Dendritic Cells Subsets in Acute SIVmac239 Infection of Chinese Rhesus Macaques
por: Xia, Hou-Jun, et al.
Publicado: (2011)

Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection
por: Evangelous, Tyler D., et al.
Publicado: (2023)

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease
por: Coffey, Lark L., et al.
Publicado: (2018)

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus
por: Pantoja, Petraleigh, et al.
Publicado: (2017)

Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
por: Hirsch, Alec J., et al.
Publicado: (2017)

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance
por: Vinton, Carol L., et al.
Publicado: (2019)

Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
por: Fernandes, Rosilainy Surubi, et al.
Publicado: (2020)

Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment
por: Bissel, Stephanie J., et al.
Publicado: (2018)

Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques
por: Carroll, Timothy, et al.
Publicado: (2017)

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus
por: Raasch, Lauren E., et al.
Publicado: (2022)

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus
por: Rosinski, Jenna R., et al.
Publicado: (2023)

EDIII-Fc induces protective immune responses against the Zika virus in mice and rhesus macaque
por: Su, Hailong, et al.
Publicado: (2023)

Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys
por: Whitney, James B., et al.
Publicado: (2014)

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy
por: Whitney, James B., et al.
Publicado: (2018)

Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
por: Dudley, Dawn M., et al.
Publicado: (2017)

African-Lineage Zika Virus Replication Dynamics and Maternal-Fetal Interface Infection in Pregnant Rhesus Macaques
por: Crooks, Chelsea M., et al.
Publicado: (2021)

Neonatal Imitation in Rhesus Macaques
por: Ferrari, Pier F, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_1p2rvecse1ighi0k6mttmevf04