Hearing Loss and Quality of Life Among Human Immunodeficiency Virus (HIV)-Infected and Uninfected Adults

BACKGROUND: Research has established that human immunodeficiency virus (HIV) causes hearing loss. Studies have yet to evaluate the impact on QOL. This project evaluates the effect of hearing loss on QOL by HIV status. METHODS: The study participants were from the Multicenter AIDS Cohort Study (MACS) and the Women’s Interagency HIV study (WIHS). A total of 248 men and 127 women participated. Pure-tone air conduction thresholds were collected for each ear at frequencies from 250 through 8000 Hz. Pure-tone averages (PTAs) for each ear were calculated as the mean of air conduction thresholds in low frequencies (i.e., 250, 500, 1,000, and 2,000 Hz) and high frequencies (i.e., 3,000, 4,000, 6,000, and 8,000 Hz). QOL (QOL) data were gathered with the Short Form 36 Health Survey and MOS-HIV instrument in the MACS and WIHS, respectively. A median regression analysis was performed to test the association of PTAs with QOL by HIV status. RESULTS: There was no significant association between hearing loss and QOL scores at low and high pure-tone averages in HIV-positive and negative individuals. HIV status, HIV biomarkers and treatment did not change the lack of association of low and high pure-tone averages with poorer QOL. CONCLUSION: Although we did not find a statistically significant association of hearing loss with QOL by HIV status, testing for hearing loss with aging and recommending treatment may offset any presumed later life decline in QOL. DISCLOSURES: All authors: No reported disclosures.