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Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups

BACKGROUND: Antibiotic consumption is considered a major driver of antibiotic resistance, but it remains unclear whether the consumption–resistance relationship is apparent for many organisms and drugs, and whether aggregate consumption is the best predictor of resistance. METHODS: We conducted a la...

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Autores principales: Olesen, Scott, Barnett, Michael, MacFadden, Derek, Lipsitch, Marc, Grad, Yonatan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632103/
http://dx.doi.org/10.1093/ofid/ofx162.047
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author Olesen, Scott
Barnett, Michael
MacFadden, Derek
Lipsitch, Marc
Grad, Yonatan H
author_facet Olesen, Scott
Barnett, Michael
MacFadden, Derek
Lipsitch, Marc
Grad, Yonatan H
author_sort Olesen, Scott
collection PubMed
description BACKGROUND: Antibiotic consumption is considered a major driver of antibiotic resistance, but it remains unclear whether the consumption–resistance relationship is apparent for many organisms and drugs, and whether aggregate consumption is the best predictor of resistance. METHODS: We conducted a landscape assessment of the consumption-resistance relationship by comparing a 20% sample of Medicare Part D outpatient antibiotic pharmacy claims with a nationwide survey of hospital antibiotic susceptibility reports. Antibiotic consumption was summarized in individual states and hospital-referral regions (HRRs) using traditional, aggregate consumption or by metrics that account for the concentration of consumption in a few individuals (Gini coefficient). The consumption–resistance relationships for 17 organism–drug combinations were simultaneously evaluated (Spearman’s rho; linear models predicting resistance from aggregate consumption and Gini coefficient) and corrected for multiple-hypothesis testing (Benjamini–Hochberg). RESULTS: We identified a significant correlation between aggregate consumption of an antibiotic and an organism’s reported resistance to that antibiotic in only a few cases: quinolones and E. coli (Spearman’s rho = 0.65, adjusted P < 10(−4)) and E. cloacae (rho = 0.50, adjusted P = 0.006). In other cases, notably E. coli with trimethoprim–sulfamethoxazole, the distribution of antibiotic consumption among consumers has a marginal relationship with antibiotic resistance (−1.0 p.p. resistance per p.p. Gini coefficient of consumption among consumers, unadjusted P < 0.001). CONCLUSION: There is a clear correlation between aggregate consumption of an antibiotic and resistance of an organism to that antibiotic in only a few cases, suggesting that antibiotic steward efforts might maximize their effectiveness by focusing on particular organisms, drugs, and consumer groups rather than overall, aggregate consumption. DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-56321032017-11-07 Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups Olesen, Scott Barnett, Michael MacFadden, Derek Lipsitch, Marc Grad, Yonatan H Open Forum Infect Dis Abstracts BACKGROUND: Antibiotic consumption is considered a major driver of antibiotic resistance, but it remains unclear whether the consumption–resistance relationship is apparent for many organisms and drugs, and whether aggregate consumption is the best predictor of resistance. METHODS: We conducted a landscape assessment of the consumption-resistance relationship by comparing a 20% sample of Medicare Part D outpatient antibiotic pharmacy claims with a nationwide survey of hospital antibiotic susceptibility reports. Antibiotic consumption was summarized in individual states and hospital-referral regions (HRRs) using traditional, aggregate consumption or by metrics that account for the concentration of consumption in a few individuals (Gini coefficient). The consumption–resistance relationships for 17 organism–drug combinations were simultaneously evaluated (Spearman’s rho; linear models predicting resistance from aggregate consumption and Gini coefficient) and corrected for multiple-hypothesis testing (Benjamini–Hochberg). RESULTS: We identified a significant correlation between aggregate consumption of an antibiotic and an organism’s reported resistance to that antibiotic in only a few cases: quinolones and E. coli (Spearman’s rho = 0.65, adjusted P < 10(−4)) and E. cloacae (rho = 0.50, adjusted P = 0.006). In other cases, notably E. coli with trimethoprim–sulfamethoxazole, the distribution of antibiotic consumption among consumers has a marginal relationship with antibiotic resistance (−1.0 p.p. resistance per p.p. Gini coefficient of consumption among consumers, unadjusted P < 0.001). CONCLUSION: There is a clear correlation between aggregate consumption of an antibiotic and resistance of an organism to that antibiotic in only a few cases, suggesting that antibiotic steward efforts might maximize their effectiveness by focusing on particular organisms, drugs, and consumer groups rather than overall, aggregate consumption. DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2017-10-04 /pmc/articles/PMC5632103/ http://dx.doi.org/10.1093/ofid/ofx162.047 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Olesen, Scott
Barnett, Michael
MacFadden, Derek
Lipsitch, Marc
Grad, Yonatan H
Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups
title Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups
title_full Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups
title_fullStr Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups
title_full_unstemmed Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups
title_short Antibiotic Consumption and Antibiotic Resistance Across Organisms, Drugs, and Consumer Groups
title_sort antibiotic consumption and antibiotic resistance across organisms, drugs, and consumer groups
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632103/
http://dx.doi.org/10.1093/ofid/ofx162.047
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