CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity

CX-4945 is a selective inhibitor of protein kinase CK2 exhibiting clinical significance. Its antitumor properties arise from the abrogation of CK2-mediated pro-survival cellular pathways. The presented data reveal the influence of CX-4945 on the growth of yeast cells showing variable potency against...

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Autores principales: Masłyk, Maciej, Janeczko, Monika, Martyna, Aleksandra, Kubiński, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632345/
https://www.ncbi.nlm.nih.gov/pubmed/28501934
http://dx.doi.org/10.1007/s11010-017-3068-z
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author Masłyk, Maciej
Janeczko, Monika
Martyna, Aleksandra
Kubiński, Konrad
author_facet Masłyk, Maciej
Janeczko, Monika
Martyna, Aleksandra
Kubiński, Konrad
author_sort Masłyk, Maciej
collection PubMed
description CX-4945 is a selective inhibitor of protein kinase CK2 exhibiting clinical significance. Its antitumor properties arise from the abrogation of CK2-mediated pro-survival cellular pathways. The presented data reveal the influence of CX-4945 on the growth of yeast cells showing variable potency against Saccharomyces cerevisiae deletion strains with different contents of CK2 subunits. The catalytic subunit CK2α appears to sensitize yeast to the CX-4945 action. Moreover, the compound suppresses hyphal growth and cell adhesion of Candida albicans, thereby abolishing some hallmarks of invasiveness of the pathogen. It is known that cancer patients are more prone to fungal infections. Our data unveil the dual-activity of CX-4945; when used in anti-cancer therapy, it may simultaneously prevent cancer-associated candidiasis.
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spelling pubmed-56323452017-10-23 CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity Masłyk, Maciej Janeczko, Monika Martyna, Aleksandra Kubiński, Konrad Mol Cell Biochem Article CX-4945 is a selective inhibitor of protein kinase CK2 exhibiting clinical significance. Its antitumor properties arise from the abrogation of CK2-mediated pro-survival cellular pathways. The presented data reveal the influence of CX-4945 on the growth of yeast cells showing variable potency against Saccharomyces cerevisiae deletion strains with different contents of CK2 subunits. The catalytic subunit CK2α appears to sensitize yeast to the CX-4945 action. Moreover, the compound suppresses hyphal growth and cell adhesion of Candida albicans, thereby abolishing some hallmarks of invasiveness of the pathogen. It is known that cancer patients are more prone to fungal infections. Our data unveil the dual-activity of CX-4945; when used in anti-cancer therapy, it may simultaneously prevent cancer-associated candidiasis. Springer US 2017-05-13 2017 /pmc/articles/PMC5632345/ /pubmed/28501934 http://dx.doi.org/10.1007/s11010-017-3068-z Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Masłyk, Maciej
Janeczko, Monika
Martyna, Aleksandra
Kubiński, Konrad
CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity
title CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity
title_full CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity
title_fullStr CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity
title_full_unstemmed CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity
title_short CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity
title_sort cx-4945: the protein kinase ck2 inhibitor and anti-cancer drug shows anti-fungal activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632345/
https://www.ncbi.nlm.nih.gov/pubmed/28501934
http://dx.doi.org/10.1007/s11010-017-3068-z
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