Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

BACKGROUND: Focal cerebral ischemia induces distinct neuroinflammatory processes. We recently reported the extracellular phosphor-glyco-protein osteopontin (OPN) to directly affect primary microglia in vitro, promoting survival while shifting their inflammatory profile towards a more neutral phenoty...

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Detalles Bibliográficos
Autores principales: Ladwig, Anne, Walter, Helene Luise, Hucklenbroich, Jörg, Willuweit, Antje, Langen, Karl-Josef, Fink, Gereon Rudolph, Rueger, Maria Adele, Schroeter, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632451/
https://www.ncbi.nlm.nih.gov/pubmed/29104378
http://dx.doi.org/10.1155/2017/7189421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632451/
https://www.ncbi.nlm.nih.gov/pubmed/29104378
http://dx.doi.org/10.1155/2017/7189421

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