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Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

BACKGROUND: Focal cerebral ischemia induces distinct neuroinflammatory processes. We recently reported the extracellular phosphor-glyco-protein osteopontin (OPN) to directly affect primary microglia in vitro, promoting survival while shifting their inflammatory profile towards a more neutral phenoty...

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Detalles Bibliográficos
Autores principales:	Ladwig, Anne, Walter, Helene Luise, Hucklenbroich, Jörg, Willuweit, Antje, Langen, Karl-Josef, Fink, Gereon Rudolph, Rueger, Maria Adele, Schroeter, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632451/ https://www.ncbi.nlm.nih.gov/pubmed/29104378 http://dx.doi.org/10.1155/2017/7189421

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