Home Remodeling and Food Allergy Interact Synergistically to Increase the Risk of Atopic Dermatitis

PURPOSE: The purpose of this study was to investigate the effects of home remodeling and food allergy (FA) on the development of atopic dermatitis (AD) in children. METHODS: The Modified International Study of Asthma and Allergies in Childhood questionnaire was used to survey 4,111 children recruited from 3 kindergartens and 6 elementary schools from Seongnam, Korea. Participants' parents agreed for them to participate in physical examinations, skin prick tests, and blood tests. RESULTS: Home remodeling in the past 12 months (adjusted odds ratio [aOR] 3.40, P = 0.006), lifetime diagnosis of FA (aOR 3.95, P < 0.001), parental history of AD (aOR 2.67, P = 0.001), and FA (aOR 2.35, P = 0.004) were independent risk factors for lifetime diagnosis of AD ever. When history of home remodeling and FA were combined, the risk for moderate-to-severe AD by scoring atopic dermatitis (SCORAD) score increased (aOR, 7.19, P = 0.011, P for interaction = 0.034). CONCLUSION: Home remodeling, lifetime diagnosis of FA, parental history of AD, and parental history of FA were independent risk factors for AD. In addition, we observed a synergistic interaction between home remodeling and FA in the risk of moderate-to-severe AD.