Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca(2+) Affinity of the Multi-C(2)-Domain Protein Otoferlin

Otoferlin is essential for fast Ca(2+)-triggered transmitter release from auditory inner hair cells (IHCs), playing key roles in synaptic vesicle release, replenishment and retrieval. Dysfunction of otoferlin results in profound prelingual deafness. Despite its crucial role in cochlear synaptic proc...

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Detalles Bibliográficos
Autores principales: Meese, Sandra, Cepeda, Andreia P., Gahlen, Felix, Adams, Christopher M., Ficner, Ralf, Ricci, Anthony J., Heller, Stefan, Reisinger, Ellen, Herget, Meike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632675/
https://www.ncbi.nlm.nih.gov/pubmed/29046633
http://dx.doi.org/10.3389/fnsyn.2017.00013

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