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Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

Pregnane X receptor (PXR) which belongs to the nuclear hormone receptor superfamily plays vital roles in several biological functions, especially in the inflammatory procedure. Besides that, PXR is revealed by recent studies to have essential effects on bone tissue. As an agonist of PXR, meclizine i...

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Detalles Bibliográficos
Autores principales:	Guo, Jiachao, Li, Weijin, Wu, Yingxing, Jing, Xingzhi, Huang, Junming, Zhang, Jiaming, Xiang, Wei, Ren, Ranyue, Lv, Zhengtao, Xiao, Jun, Guo, Fengjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632684/ https://www.ncbi.nlm.nih.gov/pubmed/29046637 http://dx.doi.org/10.3389/fphar.2017.00693

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