Cargando…

Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade

Background: Several efforts have been made to develop effective antipsychotic drugs. Currently, available antipsychotics are effective on positive symptoms, less on negative symptoms, but not on cognitive impairment, a clinically relevant dimension of schizophrenia. Drug repurposing offers great adv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torrisi, Sebastiano Alfio, Salomone, Salvatore, Geraci, Federica, Caraci, Filippo, Bucolo, Claudio, Drago, Filippo, Leggio, Gian Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632784/ https://www.ncbi.nlm.nih.gov/pubmed/29046641 http://dx.doi.org/10.3389/fphar.2017.00710

Ejemplares similares

Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone
por: Leggio, Gian Marco, et al.
Publicado: (2014)

Pharmacological and Genetic Evidence of Dopamine Receptor 3-Mediated Vasoconstriction in Isolated Mouse Aorta
por: Zingales, Veronica, et al.
Publicado: (2021)

Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2019)

Dopamine, Cognitive Impairments and Second-Generation Antipsychotics: From Mechanistic Advances to More Personalized Treatments
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2020)

The Role of Dopamine D3 Receptors, Dysbindin, and Their Functional Interaction in the Expression of Key Genes for Neuroplasticity and Neuroinflammation in the Mouse Brain
por: Rivi, Veronica, et al.
Publicado: (2023)

Long-lasting rescue of schizophrenia-relevant cognitive impairments via risperidone-loaded microPlates
por: Bellotti, Elena, et al.
Publicado: (2022)

Homology Modeling of Dopamine D(2) and D(3) Receptors: Molecular Dynamics Refinement and Docking Evaluation
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2012)

Correction: Homology Modeling of Dopamine D(2) and D(3) Receptors: Molecular Dynamics Refinement and Docking Evaluation
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2013)

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease
por: Caruso, Giuseppe, et al.
Publicado: (2021)

New drugs in psychiatry: focus on new pharmacological targets
por: Caraci, Filippo, et al.
Publicado: (2017)

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ(1-42) Oligomers in Mice: A Key Role of Transforming Growth Factor-β1
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2019)

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2017)

A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice
por: Torrisi, Sebastiano A., et al.
Publicado: (2020)

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model
por: Yang, Bangkun, et al.
Publicado: (2016)

Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p Is Associated with Modulation of BDNF and FKBP5 in Brain Areas of PTSD-Related Susceptible and Resilient Mice
por: Maurel, Oriana Maria, et al.
Publicado: (2021)

A New Human Blood–Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes
por: Fresta, Claudia G., et al.
Publicado: (2020)

Intra-Accumbens Injection of a Dopamine Aptamer Abates MK-801-Induced Cognitive Dysfunction in a Model of Schizophrenia
por: Holahan, Matthew R., et al.
Publicado: (2011)

New antipsychotic drugs for the treatment of agitation and psychosis in Alzheimer’s disease: focus on brexpiprazole and pimavanserin
por: Caraci, Filippo, et al.
Publicado: (2020)

Carnosine Counteracts the Molecular Alterations Aβ Oligomers-Induced in Human Retinal Pigment Epithelial Cells
por: Caruso, Giuseppe, et al.
Publicado: (2023)

Prenatal stress induces a depressive-like phenotype in adolescent rats: The key role of TGF-β1 pathway
por: Fidilio, Annamaria, et al.
Publicado: (2022)

Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy
por: Bucolo, Claudio, et al.
Publicado: (2013)

The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia
por: Xu, Jinwei, et al.
Publicado: (2022)

Quetiapine Attenuates Schizophrenia-Like Behaviors and Demyelination in a MK-801–Induced Mouse Model of Schizophrenia
por: He, Jue, et al.
Publicado: (2020)

Retinal Protection and Distribution of Curcumin in Vitro and in Vivo
por: Platania, Chiara B. M., et al.
Publicado: (2018)

Imputed expression of schizophrenia‐associated genes and cognitive measures in patients with schizophrenia
por: Fabbri, Chiara, et al.
Publicado: (2022)

The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801
por: Kruk-Slomka, Marta, et al.
Publicado: (2016)

Cannabidiol Attenuates MK-801-Induced Cognitive Symptoms of Schizophrenia in the Passive Avoidance Test in Mice
por: Kruk-Slomka, Marta, et al.
Publicado: (2021)

Retinal biomarkers and pharmacological targets for Hermansky-Pudlak syndrome 7
por: Romano, Giovanni Luca, et al.
Publicado: (2020)

Acute stress alters recognition memory and AMPA/NMDA receptor subunits in a sex-dependent manner
por: Torrisi, Sebastiano A., et al.
Publicado: (2023)

MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia
por: Guest, Paul C., et al.
Publicado: (2015)

Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801
por: Bygrave, A M, et al.
Publicado: (2016)

Galphimia glauca and Natural Galphimines Block Schizophrenia-Like Symptoms Induced with Apomorphine and MK-801 in Mice
por: Santillán-Urquiza, Mayra Alejandra, et al.
Publicado: (2019)

Paeoniflorin Rescued MK-801-Induced Schizophrenia–Like Behaviors in Mice via Oxidative Stress Pathway
por: Liang, Jia-Quan, et al.
Publicado: (2022)

Effects of Icariin and Its Metabolites on GPCR Regulation and MK-801-Induced Schizophrenia-Like Behaviors in Mice
por: Seong, Su Hui, et al.
Publicado: (2023)

Effect of MK-801 and Clozapine on the Proteome of Cultured Human Oligodendrocytes
por: Cassoli, Juliana S., et al.
Publicado: (2016)

Effect of Vaccinium macrocarpon on MK-801-induced psychosis in mice
por: Shukla, Disha, et al.
Publicado: (2018)

Potential drug mechanism(s) targeting the contractile status of hepatic stellate cells
por: Bucolo, Claudio, et al.
Publicado: (2012)

Ocular drug delivery: a clue from nanotechnology
por: Bucolo, Claudio, et al.
Publicado: (2012)

Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach
por: Platania, Chiara B. M., et al.
Publicado: (2015)

Investigation of the synergistic effects of haloperidol combined with Calculus Bovis Sativus in treating MK-801-induced schizophrenia in rats
por: Lei, Kai, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_64iblav3517iancs6pfncfg685