A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

BACKGROUND: The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of antimalarials. Exploratory data suggested that the combination of artefenomel and piperaquine phosphate (PQP) has the potential to achieve sa...

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Detalles Bibliográficos
Autores principales: Macintyre, Fiona, Adoke, Yeka, Tiono, Alfred B., Duong, Tran Thanh, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Tinto, Halidou, Bassat, Quique, Issifou, Saadou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart E., Biguenet, Sophie, Kibuuka, Afizi, Tshefu, Antoinette Kitoto, Smith, Melnick, Foster, Chanelle, Leipoldt, Illse, Kremsner, Peter G., Phuc, Bui Quang, Ouedraogo, Alphonse, Ramharter, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632828/
https://www.ncbi.nlm.nih.gov/pubmed/28988541
http://dx.doi.org/10.1186/s12916-017-0940-3

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