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Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint

In zygotes, DNA damage delays the first cleavage to enable repair. Our previous study found that 0.03 mM hydrogen peroxide (H(2)O(2)) was the minimum concentration required for induction of oxidative DNA damage in mouse zygotes and that this represented the most similar situation to the clinical phe...

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Detalles Bibliográficos
Autores principales:	Wu, Que, Li, Zhiling, Huang, Yue, Qian, Diting, Chen, Man, Xiao, Wanfen, Wang, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632912/ https://www.ncbi.nlm.nih.gov/pubmed/29147457 http://dx.doi.org/10.1155/2017/2103190

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