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Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line
Chronic inflammation is associated with cancer. CXCL8 promotes tumor microenvironment construction through recruiting leukocytes and endothelial progenitor cells that are involved in angiogenesis. It also enhances tumor cell proliferation and migration. Metformin, type II diabetes medication, demons...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632916/ https://www.ncbi.nlm.nih.gov/pubmed/29147073 http://dx.doi.org/10.1155/2017/6589423 |
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author | Xiao, Zhihui Wu, Wenjun Poltoratsky, Vladimir |
author_facet | Xiao, Zhihui Wu, Wenjun Poltoratsky, Vladimir |
author_sort | Xiao, Zhihui |
collection | PubMed |
description | Chronic inflammation is associated with cancer. CXCL8 promotes tumor microenvironment construction through recruiting leukocytes and endothelial progenitor cells that are involved in angiogenesis. It also enhances tumor cell proliferation and migration. Metformin, type II diabetes medication, demonstrates anticancer properties via suppressing inflammation, tumor cell proliferation, angiogenesis, and metastasis. This study intended to address the role of metformin in regulation of CXCL8 expression and cell proliferation and migration. Our data indicated that metformin suppressed LPS-induced CXCL8 expression in a dose-dependent manner through inhibiting NF-κB, but not AP-1 and C/EBP, activities under the conditions we used. This inhibitory effect of metformin is achieved through dampening LPS-induced NF-κB nuclear translocation. Cell migration was inhibited by metformin under high dose (10 mM), but not cell proliferation. |
format | Online Article Text |
id | pubmed-5632916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56329162017-11-16 Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line Xiao, Zhihui Wu, Wenjun Poltoratsky, Vladimir Mediators Inflamm Research Article Chronic inflammation is associated with cancer. CXCL8 promotes tumor microenvironment construction through recruiting leukocytes and endothelial progenitor cells that are involved in angiogenesis. It also enhances tumor cell proliferation and migration. Metformin, type II diabetes medication, demonstrates anticancer properties via suppressing inflammation, tumor cell proliferation, angiogenesis, and metastasis. This study intended to address the role of metformin in regulation of CXCL8 expression and cell proliferation and migration. Our data indicated that metformin suppressed LPS-induced CXCL8 expression in a dose-dependent manner through inhibiting NF-κB, but not AP-1 and C/EBP, activities under the conditions we used. This inhibitory effect of metformin is achieved through dampening LPS-induced NF-κB nuclear translocation. Cell migration was inhibited by metformin under high dose (10 mM), but not cell proliferation. Hindawi 2017 2017-09-24 /pmc/articles/PMC5632916/ /pubmed/29147073 http://dx.doi.org/10.1155/2017/6589423 Text en Copyright © 2017 Zhihui Xiao et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Xiao, Zhihui Wu, Wenjun Poltoratsky, Vladimir Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line |
title | Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line |
title_full | Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line |
title_fullStr | Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line |
title_full_unstemmed | Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line |
title_short | Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line |
title_sort | metformin suppressed cxcl8 expression and cell migration in hek293/tlr4 cell line |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632916/ https://www.ncbi.nlm.nih.gov/pubmed/29147073 http://dx.doi.org/10.1155/2017/6589423 |
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