TOP1MT deficiency promotes GC invasion and migration via the enhancements of LDHA expression and aerobic glycolysis

Aerobic glycolysis plays an important role in cancer progression. New target genes regulating cancer aerobic glycolysis must be explored to improve patient prognosis. Mitochondrial topoisomerase I (TOP1MT) deficiency suppresses glucose oxidative metabolism but enhances glycolysis in normal cells. He...

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Detalles Bibliográficos
Autores principales: Wang, Hongqiang, Zhou, Rui, Sun, Li, Xia, Jianling, Yang, Xuchun, Pan, Changqie, Huang, Na, Shi, Min, Bin, Jianping, Liao, Yulin, Liao, Wangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633043/
https://www.ncbi.nlm.nih.gov/pubmed/28874393
http://dx.doi.org/10.1530/ERC-17-0058

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