Cargando…

Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver

Protein kinase B (PKB/Akt) plays important roles in the regulation of lipid homeostasis, and impairment of Akt activity has been demonstrated to be involved in the development of non-alcoholic fatty liver disease (NAFLD). Previous studies suggest that cytochrome P4502E1 (CYP2E1) plays causal roles i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Tao, Zhang, Cui-Li, Zhao, Ning, Guan, Min-Jie, Xiao, Mo, Yang, Rui, Zhao, Xiu-Lan, Yu, Li-Hua, Zhu, Zhen-Ping, Xie, Ke-Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633250/ https://www.ncbi.nlm.nih.gov/pubmed/28987868 http://dx.doi.org/10.1016/j.redox.2017.09.018

Ejemplares similares

Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway
por: Zhang, Cui-Li, et al.
Publicado: (2015)

CMZ Reversed Chronic Ethanol-Induced Disturbance of PPAR-α Possibly by Suppressing Oxidative Stress and PGC-1α Acetylation, and Activating the MAPK and GSK3β Pathway
por: Zeng, Tao, et al.
Publicado: (2014)

The Involvement of Acetaldehyde in Ethanol-Induced Cell Cycle Impairment
por: Scheer, Marc A., et al.
Publicado: (2016)

Acute Ethanol Inhibition of γ Oscillations Is Mediated by Akt and GSK3β
por: Wang, JianGang, et al.
Publicado: (2016)

Garlic Oil Attenuated Nitrosodiethylamine-Induced Hepatocarcinogenesis by Modulating the Metabolic Activation and Detoxification Enzymes
por: Zhang, Cui-Li, et al.
Publicado: (2013)

Protective Effects of Garlic Oil on Hepatocarcinoma Induced by N-Nitrosodiethylamine in Rats
por: Zhang, Cui-Li, et al.
Publicado: (2012)

Polydatin Protects Rat Liver against Ethanol-Induced Injury: Involvement of CYP2E1/ROS/Nrf2 and TLR4/NF-κB p65 Pathway
por: Huang, Qiong-Hui, et al.
Publicado: (2017)

Ethanol‐induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity
por: Rasineni, Karuna, et al.
Publicado: (2017)

Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats
por: Liu, Lei, et al.
Publicado: (2023)

Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway
por: Wu, Jingxian, et al.
Publicado: (2013)

Modulation of Fatty Acid Composition of Aspergillus oryzae in Response to Ethanol Stress
por: Ma, Long, et al.
Publicado: (2019)

Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification
por: Wu, Jie, et al.
Publicado: (2017)

High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2
por: Wang, Xing-he, et al.
Publicado: (2017)

Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth
por: Li, Chu-Wen, et al.
Publicado: (2013)

Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways
por: Meng, Yong, et al.
Publicado: (2018)

Metabolic syndrome in rats is associated with erectile dysfunction by impairing PI3K/Akt/eNOS activity
por: Li, Rui, et al.
Publicado: (2017)

Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity
por: Lu, Yongke, et al.
Publicado: (2015)

Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1
por: Li, Deng-Ke, et al.
Publicado: (2017)

Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1
por: Wang, Yalan, et al.
Publicado: (2023)

Intra‐ischemic hypothermia cardioprotection involves modulation of PTEN/Akt/ERK signaling and fatty acid oxidation
por: Justice, Cody N., et al.
Publicado: (2023)

Translocation of vaginal microbiota is involved in impairment and protection of uterine health
por: Wang, Jinfeng, et al.
Publicado: (2021)

Transcriptome Analysis of CYP450 Family Members in Fritillaria cirrhosa D. Don and Profiling of Key CYP450s Related to Isosteroidal Alkaloid Biosynthesis
por: Li, Rui, et al.
Publicado: (2023)

A Systematically Combined Genotype and Functional Combination Analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in Different Geographic Areas of Mainland China – A Basis for Personalized Therapy
por: Wu, Zhenqiang, et al.
Publicado: (2013)

Progerin modulates the IGF-1R/Akt signaling involved in aging
por: Jiang, Bo, et al.
Publicado: (2022)

Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis
por: Zeng, Tao, et al.
Publicado: (2013)

The possible mechanisms of CYP2E1 interactions with HSP90 and the influence of ethanol on them
por: Kitam, Volodymyr O, et al.
Publicado: (2012)

Intracellular ethanol‐mediated oxidation and apoptosis in HepG2/CYP2E1 cells impaired by two active peptides from seahorse (Hippocampus kuda bleeler) protein hydrolysates via the Nrf2/HO‐1 and akt pathways
por: Qian, Zhong‐Ji, et al.
Publicado: (2021)

Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers
por: Qiu, Furong, et al.
Publicado: (2013)

CYP1B1-AS1 Is a Novel Biomarker in Glioblastoma by Comprehensive Analysis
por: Ye, Tao, et al.
Publicado: (2021)

CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS-induced lipid peroxidation and inflammation
por: Gao, Huifang, et al.
Publicado: (2020)

Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer
por: Liu, Xiao-yun, et al.
Publicado: (2020)

Case Report: A combination of chimeric CYP11B2/CYP11B1 and a novel p.Val68Gly CYP11B1 variant causing 11β-Hydroxylase deficiency in a Chinese patient
por: Li, Jialin, et al.
Publicado: (2023)

Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein
por: Yang, Jia-Ming, et al.
Publicado: (2012)

Epigenetic Mechanisms Are Involved in the Regulation of Ethanol Consumption in Mice
por: Qiang, Mei, et al.
Publicado: (2015)

Intermittent Hypoxia Inhibits Hepatic CYP1a2 Expression and Delays Aminophylline Metabolism
por: Zhang, Xiao-Bin, et al.
Publicado: (2022)

Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus
por: Guo, Yanxia, et al.
Publicado: (2022)

A study of the substance dependence effect of the ethanolic extract and iridoid-rich fraction from Valeriana jatamansi Jones in mice
por: Yu, Lin, et al.
Publicado: (2015)

Impaired lung function is associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in middle-aged and elderly Chinese
por: Qin, Li, et al.
Publicado: (2017)

LECT2 Ameliorates Blood–Retinal Barrier Impairment Secondary to Diabetes Via Activation of the Tie2/Akt/mTOR Signaling Pathway
por: Qin, Yuan-Jun, et al.
Publicado: (2022)

Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6
por: Gao, Li-Na, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_8hsf9bukgrgq9m1gua7ujgoum8