Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

Y-box binding protein-1 (YB-1), involved in cancer progression and chemoradiation resistance, is overexpressed in not only cancer cells but also tumor blood vessels. In this study, we investigated the potential value of amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) tar...

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Detalles Bibliográficos
Autores principales: Setoguchi, Kiyoko, Cui, Lin, Hachisuka, Nobutaka, Obchoei, Sumalee, Shinkai, Kentaro, Hyodo, Fuminori, Kato, Kiyoko, Wada, Fumito, Yamamoto, Tsuyoshi, Harada-Shiba, Mariko, Obika, Satoshi, Nakano, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633255/
https://www.ncbi.nlm.nih.gov/pubmed/29246296
http://dx.doi.org/10.1016/j.omtn.2017.09.004

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