Cargando…

L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance

Emergence of Amphotericin B (AmB) resistant Leishmania donovani has posed major therapeutic challenge against the parasite. Consequently, combination therapy aimed at multiple molecular targets, based on proteome wise network analysis has been recommended. In this regard we had earlier identified an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Jasdeep, Khan, Mohd Imran, Singh Yadav, Shiv Pratap, Srivastava, Ankit, Sinha, Kislay K., Ashish, Das, Pradeep, Kundu, Bishwajit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633258/ https://www.ncbi.nlm.nih.gov/pubmed/28988014 http://dx.doi.org/10.1016/j.ijpddr.2017.09.003

Ejemplares similares

HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani
por: Jha, Pravin K., et al.
Publicado: (2017)

Stage-Dependent Expression and Up-Regulation of Trypanothione Synthetase in Amphotericin B Resistant Leishmania donovani
por: Equbal, Asif, et al.
Publicado: (2014)

Oxidative Stress-Mediated Overexpression of Uracil DNA Glycosylase in Leishmania donovani Confers Tolerance against Antileishmanial Drugs
por: Mishra, Anshul, et al.
Publicado: (2018)

Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress
por: Singh, Kuljit, et al.
Publicado: (2017)

In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani
por: Saha, Subhadip, et al.
Publicado: (2022)

Pharmacodynamics and cellular accumulation of amphotericin B and miltefosine in Leishmania donovani-infected primary macrophages
por: Voak, Andrew A, et al.
Publicado: (2018)

Intracellular zinc flux causes reactive oxygen species mediated mitochondrial dysfunction leading to cell death in Leishmania donovani
por: Kumari, Anjali, et al.
Publicado: (2017)

Heat induces end to end repetitive association in P. furiosusl-asparaginase which enables its thermophilic property
por: Sharma, Pankaj, et al.
Publicado: (2020)

Apoptosis-like cell death in Leishmania donovani treated with KalsomeTM10, a new liposomal amphotericin B
por: Shadab, Md., et al.
Publicado: (2017)

Biochemical and biophysical characterization of Leishmania donovani gamma-glutamylcysteine synthetase
por: Agnihotri, Pragati, et al.
Publicado: (2016)

Seasonal Variation in the Prevalence of Sand Flies Infected with Leishmania donovani
por: Tiwary, Puja, et al.
Publicado: (2013)

Unravelling the rate of action of hits in the Leishmania donovani box using standard drugs amphotericin B and miltefosine
por: Tegazzini, Diana, et al.
Publicado: (2017)

Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani
por: Singh, Saurabh Pratap, et al.
Publicado: (2013)

Leishmania donovani infection induce differential miRNA expression in CD4+ T cells
por: Kumar, Vinod, et al.
Publicado: (2020)

Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b
por: Singh, Ruby, et al.
Publicado: (2016)

Vaccine Development Against Leishmania donovani
por: Das, Amrita, et al.
Publicado: (2012)

Attenuation and Production of the Amphotericin B-Resistant Leishmania tropica Strain
por: Khan, Imran, et al.
Publicado: (2016)

Leishmania donovani Secretory Mevalonate Kinase Regulates Host Immune Response and Facilitates Phagocytosis
por: Bamra, Tanvir, et al.
Publicado: (2021)

Latent Infection with Leishmania donovani in Highly Endemic Villages in Bihar, India
por: Hasker, Epco, et al.
Publicado: (2013)

Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management
por: Sardar, Abul Hasan, et al.
Publicado: (2016)

Retraction Note to: Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b
por: Singh, Ruby, et al.
Publicado: (2022)

Identification of Leishmania donovani antigen in circulating immune complexes of visceral leishmaniasis subjects for diagnosis
por: Jamal, Fauzia, et al.
Publicado: (2017)

On Transient Infections with Leishmania Donovani in Man and Animals
por: Knowles, R., et al.
Publicado: (1924)

Genome Plasticity in Cultured Leishmania donovani: Comparison of Early and Late Passages
por: Sinha, Roma, et al.
Publicado: (2018)

The potential HLA Class I-restricted epitopes derived from LeIF and TSA of Leishmania donovani evoke anti-leishmania CD8+ T lymphocyte response
por: Dikhit, Manas Ranjan, et al.
Publicado: (2018)

LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD
por: Young, Charles W., et al.
Publicado: (1923)

Correction: Latent Infection with Leishmania donovani in Highly Endemic Villages in Bihar, India
por: Hasker, Epco, et al.
Publicado: (2013)

Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner
por: Abhishek, Kumar, et al.
Publicado: (2018)

Identification and Characterization of miRNAs in Response to Leishmania donovani Infection: Delineation of Their Roles in Macrophage Dysfunction
por: Tiwari, Neeraj, et al.
Publicado: (2017)

Dynamicity in Host Metabolic Adaptation Is Influenced by the Synergistic Effect of Eugenol Oleate and Amphotericin B During Leishmania donovani Infection In Vitro
por: Kar, Amrita, et al.
Publicado: (2021)

Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani
por: Dikhit, Manas R, et al.
Publicado: (2016)

Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation
por: Singh, Shalini, et al.
Publicado: (2016)

Spike Protein Mutation-Induced Changes in the Kinetic and Thermodynamic Behavior of Its Receptor Binding Domains Explain Their Higher Propensity to Attain Open States in SARS-CoV-2 Variants of Concern
por: Singh, Jasdeep, et al.
Publicado: (2023)

Corrigendum: Identification and Characterization of miRNAs in Response to Leishmania donovani Infection: Delineation of Their Roles in Macrophage Dysfunction
por: Tiwari, Neeraj, et al.
Publicado: (2017)

Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani
por: Das, Sanchita, et al.
Publicado: (2015)

Role of inhibitors of serine peptidases in protecting Leishmania donovani against the hydrolytic peptidases of sand fly midgut
por: Verma, Sudha, et al.
Publicado: (2017)

Proteomic analysis of the secretome of Leishmania donovani
por: Silverman, J Maxwell, et al.
Publicado: (2008)

Surface antigens of Leishmania donovani promastigotes
Publicado: (1983)

Leishmania donovani bodies in bone marrow
por: Ali, Natasha, et al.
Publicado: (2014)

Computational Elucidation of Structural Basis for Ligand Binding with Leishmania donovani Adenosine Kinase
por: Kar, Rajiv K., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5aontkp1k6ppf4ljm05geh7532