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Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

BACKGROUND: Vitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD. MATERIALS AND METHODS: U...

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Autores principales: Moradi, Maryam, Foroutanfar, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633284/
https://www.ncbi.nlm.nih.gov/pubmed/29042790
http://dx.doi.org/10.2147/VHRM.S142721
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author Moradi, Maryam
Foroutanfar, Ali
author_facet Moradi, Maryam
Foroutanfar, Ali
author_sort Moradi, Maryam
collection PubMed
description BACKGROUND: Vitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD. MATERIALS AND METHODS: Using a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques). RESULTS: The mean age of the participants was 60.5±10.6 years and the mean serum vitamin D level was 26.2±15.9 ng/dL (range, 3.5–83.2 ng/dL). Overall, 6.1% of the participants (n=11) had vitamin D deficiency, 56.1% (n=101) had insufficient levels of vitamin D, and 37.8% (n=68) had sufficient levels of vitamin D. The mean serum vitamin D level was significantly lower in patients with severe CAD (P=0.004). The serum vitamin D level in the “positive for CAD” group was 20.98 ng/mL, significantly lower than the level in the “negative for CAD” group (30.47 ng/mL; P<0.001). The mean calcium score among participants was 533.5±87.9. Based on the Spearman test, a significant negative correlation (−0.21) was detected between the serum vitamin D level and coronary artery calcium score (CACS) (P=0.005). Conversely, the mean CACS in the vitamin D deficient group was significantly higher than in the insufficient and sufficient vitamin D groups (P<0.001 for both comparisons). CONCLUSION: Vitamin D deficiency was associated with coronary artery calcification and severity of coronary artery stenosis in Iranian patients.
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spelling pubmed-56332842017-10-17 Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population Moradi, Maryam Foroutanfar, Ali Vasc Health Risk Manag Original Research BACKGROUND: Vitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD. MATERIALS AND METHODS: Using a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques). RESULTS: The mean age of the participants was 60.5±10.6 years and the mean serum vitamin D level was 26.2±15.9 ng/dL (range, 3.5–83.2 ng/dL). Overall, 6.1% of the participants (n=11) had vitamin D deficiency, 56.1% (n=101) had insufficient levels of vitamin D, and 37.8% (n=68) had sufficient levels of vitamin D. The mean serum vitamin D level was significantly lower in patients with severe CAD (P=0.004). The serum vitamin D level in the “positive for CAD” group was 20.98 ng/mL, significantly lower than the level in the “negative for CAD” group (30.47 ng/mL; P<0.001). The mean calcium score among participants was 533.5±87.9. Based on the Spearman test, a significant negative correlation (−0.21) was detected between the serum vitamin D level and coronary artery calcium score (CACS) (P=0.005). Conversely, the mean CACS in the vitamin D deficient group was significantly higher than in the insufficient and sufficient vitamin D groups (P<0.001 for both comparisons). CONCLUSION: Vitamin D deficiency was associated with coronary artery calcification and severity of coronary artery stenosis in Iranian patients. Dove Medical Press 2017-10-04 /pmc/articles/PMC5633284/ /pubmed/29042790 http://dx.doi.org/10.2147/VHRM.S142721 Text en © 2017 Moradi and Foroutanfar. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Moradi, Maryam
Foroutanfar, Ali
Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population
title Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population
title_full Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population
title_fullStr Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population
title_full_unstemmed Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population
title_short Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population
title_sort evaluation of vitamin d levels in relation to coronary ct angiographic findings in an iranian population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633284/
https://www.ncbi.nlm.nih.gov/pubmed/29042790
http://dx.doi.org/10.2147/VHRM.S142721
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