Cargando…

Low dose of kaempferol suppresses the migration and invasion of triple-negative breast cancer cells by downregulating the activities of RhoA and Rac1

PURPOSE: Triple-negative breast cancer (TNBC) is an especially aggressive and hard-to-treat disease. Although the anticancer role of kaempferol has been reported in breast cancer, the effect of kaempferol on TNBC remains unclear. MATERIALS AND METHODS: This experiment investigated the migration-supp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shoushan, Yan, Ting, Deng, Rong, Jiang, Xuesong, Xiong, Huaping, Wang, Yuan, Yu, Qiao, Wang, Xiaohua, Chen, Cheng, Zhu, Yichao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633285/ https://www.ncbi.nlm.nih.gov/pubmed/29042792 http://dx.doi.org/10.2147/OTT.S140886

Ejemplares similares

Downregulation of Dock1 and Elmo1 suppresses the migration and invasion of triple-negative breast cancer epithelial cells through the RhoA/Rac1 pathway
por: Liang, Yueyang, et al.
Publicado: (2018)

MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell–cell junctions in epithelial cells
por: Breznau, Elaina B., et al.
Publicado: (2015)

Astaxanthin induces migration in human skin keratinocytes via Rac1 activation and RhoA inhibition
por: Ritto, Dakanda, et al.
Publicado: (2017)

Roles of the small GTPases RhoA and Rac1 in cell behavior
por: Otey, Carol, et al.
Publicado: (2009)

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
por: Henneman, L., et al.
Publicado: (2010)

Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA
por: Wang, Junyi, et al.
Publicado: (2021)

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases
por: Jou, Tzuu-Shuh, et al.
Publicado: (1998)

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac
por: Fang, Xiang, et al.
Publicado: (2004)

Paxillin and Hic-5 Interaction with Vinculin Is Differentially Regulated by Rac1 and RhoA
por: Deakin, Nicholas O., et al.
Publicado: (2012)

Activation of Rac-1 and RhoA Contributes to Podocyte Injury in Chronic Kidney Disease
por: Babelova, Andrea, et al.
Publicado: (2013)

Arhgap28 Is a RhoGAP that Inactivates RhoA and Downregulates Stress Fibers
por: Yeung, Ching-Yan Chloé, et al.
Publicado: (2014)

Interleukin-8 Induces the Endothelial Cell Migration through the Activation of Phosphoinositide 3-Kinase-Rac1/RhoA Pathway
por: Lai, Yi, et al.
Publicado: (2011)

Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 Signaling
por: Sabbatini, Maria Eugenia, et al.
Publicado: (2013)

Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry
por: Li, Liwen, et al.
Publicado: (2016)

Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite
por: Kim, Sang-Yeob, et al.
Publicado: (2017)

RhoA and Rac1 in Liver Cancer Cells: Induction of Overexpression Using Mechanical Stimulation
por: Yadav, Sharda, et al.
Publicado: (2020)

O-GlcNAcylation promotes migration and invasion in human ovarian cancer cells via the RhoA/ROCK/MLC pathway
por: Niu, Yichao, et al.
Publicado: (2017)

A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion
por: Hetmanski, Joseph H. R., et al.
Publicado: (2016)

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex
por: Jacquemet, Guillaume, et al.
Publicado: (2013)

Dynamic functions of RhoA in tumor cell migration and invasion
por: O'Connor, Kathleen, et al.
Publicado: (2013)

Rac1/RhoA antagonism defines cell-to-cell heterogeneity during epidermal morphogenesis in nematodes
por: Martin, Emmanuel, et al.
Publicado: (2016)

RhoA improves cryopreservation of rooster sperm through the Rho/RhoA-associated kinase/cofilin pathway
por: Heng, Nuo, et al.
Publicado: (2022)

The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis
por: Zhang, Donglei, et al.
Publicado: (2015)

RhoA suppresses pseudorabies virus replication in vitro
por: Li, Xin-Man, et al.
Publicado: (2023)

A RhoC Biosensor Reveals Differences in the Activation Kinetics of RhoA and RhoC in Migrating Cells
por: Zawistowski, Jon S., et al.
Publicado: (2013)

Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling
por: Zhang, Jason Z., et al.
Publicado: (2020)

PKCα-mediated phosphorylation of the diacylglycerol kinase ζ MARCKS domain switches cell migration modes by regulating interactions with Rac1 and RhoA
por: Ard, Ryan, et al.
Publicado: (2021)

Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activating RhoA and Rac1 GTPase
por: Lv, Qingyu, et al.
Publicado: (2014)

Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement
por: Zhang, Xun E., et al.
Publicado: (2016)

Actin-Mediated Gene Expression Depends on RhoA and Rac1 Signaling in Proximal Tubular Epithelial Cells
por: Giehl, Klaudia, et al.
Publicado: (2015)

NKCC1 promotes EMT‐like process in GBM via RhoA and Rac1 signaling pathways
por: Ma, Haiwen, et al.
Publicado: (2018)

RhoA is required for monocyte tail retraction during transendothelial migration
por: Worthylake, Rebecca A., et al.
Publicado: (2001)

RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA
por: Howe, Grant A, et al.
Publicado: (2012)

RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
por: Jackson, Ben, et al.
Publicado: (2011)

Hesperetin Inhibits TGF-β1-Induced Migration and Invasion of Triple Negative Breast Cancer MDA-MB-231 Cells via Suppressing Fyn/Paxillin/RhoA Pathway
por: Lu, Qian, et al.
Publicado: (2022)

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF
por: Yoshida, Tatsushi, et al.
Publicado: (2016)

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets
por: Vega, Francisco M., et al.
Publicado: (2011)

Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells
por: Perry, Nicole A., et al.
Publicado: (2014)

RhoA/Rho kinase in spinal cord injury
por: Wu, Xiangbing, et al.
Publicado: (2016)

Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity
por: Jou, Tzuu-Shuh, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_h48g6etuougj1oskkrde11vlqf