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Rational Design of Short Locked Nucleic Acid-Modified 2′-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro

Locked nucleic acid is a prominent nucleic acid analog with unprecedented target binding affinity to cDNA and RNA oligonucleotides and shows remarkable stability against nuclease degradation. Incorporation of locked nucleic acid nucleotides into an antisense oligonucleotide (AO) sequence can reduce...

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Detalles Bibliográficos
Autores principales:	Le, Bao T., Adams, Abbie M., Fletcher, Susan, Wilton, Stephen D., Veedu, Rakesh N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633351/ https://www.ncbi.nlm.nih.gov/pubmed/29246294 http://dx.doi.org/10.1016/j.omtn.2017.09.002

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