Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in Saccharomyces cerevisiae

Topoisomerase II (Top2) is an essential protein that resolves DNA catenations. When Top2 is inactivated, mitotic catastrophe results from massive entanglement of chromosomes. Top2 is also the target of many first-line anticancer drugs, the so-called Top2 poisons. Often, tumors become resistant to th...

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Detalles Bibliográficos
Autores principales: Ramos-Pérez, Cristina, Ayra-Plasencia, Jessel, Matos-Perdomo, Emiliano, Lisby, Michael, Brown, Grant W., Machín, Félix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633387/
https://www.ncbi.nlm.nih.gov/pubmed/28839115
http://dx.doi.org/10.1534/g3.117.300104

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