ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

Activating transcription factor 4 (ATF4) is a critical mediator of metabolic and oxidative homeostasis and cell survival. ATF4 is elevated in response to diverse microenvironmental stresses, including starvation, ER stress damages and exposure to toxic factors. Here we show that ATF4 expression fost...

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Detalles Bibliográficos
Autores principales: Chen, D, Fan, Z, Rauh, M, Buchfelder, M, Eyupoglu, I Y, Savaskan, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633655/
https://www.ncbi.nlm.nih.gov/pubmed/28553953
http://dx.doi.org/10.1038/onc.2017.146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633655/
https://www.ncbi.nlm.nih.gov/pubmed/28553953
http://dx.doi.org/10.1038/onc.2017.146

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