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ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
Activating transcription factor 4 (ATF4) is a critical mediator of metabolic and oxidative homeostasis and cell survival. ATF4 is elevated in response to diverse microenvironmental stresses, including starvation, ER stress damages and exposure to toxic factors. Here we show that ATF4 expression fost...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633655/ https://www.ncbi.nlm.nih.gov/pubmed/28553953 http://dx.doi.org/10.1038/onc.2017.146 |