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A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants
OBJECTIVES: Medicinal plants are vital sources of bioactive compounds that are useful for the treatment of patients with snake bites or are indirectly applicable for boosting the effects of conventional serum therapy. These plants are being used traditionally by local healers and tribes for the trea...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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the Korean Pharmacopuncture Institute (KPI)
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633669/ https://www.ncbi.nlm.nih.gov/pubmed/30087793 http://dx.doi.org/10.3831/KPI.2017.20.020 |
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author | Singh, Pushpendra Yasir, Mohammad Hazarika, Risha Sugunan, Sunisha Shrivastava, Rahul |
author_facet | Singh, Pushpendra Yasir, Mohammad Hazarika, Risha Sugunan, Sunisha Shrivastava, Rahul |
author_sort | Singh, Pushpendra |
collection | PubMed |
description | OBJECTIVES: Medicinal plants are vital sources of bioactive compounds that are useful for the treatment of patients with snake bites or are indirectly applicable for boosting the effects of conventional serum therapy. These plants are being used traditionally by local healers and tribes for the treatment of patients with snake bites and therefore can be used as an alternative against snake envenomation. Scientifically, using the secondary metabolites of plants to neutralize venom enzymes has an extra benefit of being based on traditional knowledge; also, the use of such metabolites for the treatment of patients with snake bites is cheaper and the treatment can be started sooner. METHODS: All the available information on various secondary metabolites exhibiting venom neutralizing ability were collected via electronic search (using Google books, Pubmed, SciFinder, Scirus, Google Scholar, and Web of Science) and articles of peer-reviewed journals. RESULTS: Recent interest in different plant has focused on isolating and identifying of different phytoconstituents that exhibit Phospholipase A2 activity and other venom enzyme neutralizing ability. In this support convincing evidence in experimental animal models are available. CONCLUSION: Secondary metabolites are naturally present, have no side effect, are stable for a long time, can be easily stored, and can neutralize a wide range of snake enzymes, such as phospholipase A2, hyaluronidase, protease, L-amino acid oxidase, 5′nucleotidase, etc. The current review presents a compilation of important plant secondary metabolites that are effective against snake venom due to enzyme neutralization. |
format | Online Article Text |
id | pubmed-5633669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | the Korean Pharmacopuncture Institute (KPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-56336692018-08-07 A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants Singh, Pushpendra Yasir, Mohammad Hazarika, Risha Sugunan, Sunisha Shrivastava, Rahul J Pharmacopuncture Review Article OBJECTIVES: Medicinal plants are vital sources of bioactive compounds that are useful for the treatment of patients with snake bites or are indirectly applicable for boosting the effects of conventional serum therapy. These plants are being used traditionally by local healers and tribes for the treatment of patients with snake bites and therefore can be used as an alternative against snake envenomation. Scientifically, using the secondary metabolites of plants to neutralize venom enzymes has an extra benefit of being based on traditional knowledge; also, the use of such metabolites for the treatment of patients with snake bites is cheaper and the treatment can be started sooner. METHODS: All the available information on various secondary metabolites exhibiting venom neutralizing ability were collected via electronic search (using Google books, Pubmed, SciFinder, Scirus, Google Scholar, and Web of Science) and articles of peer-reviewed journals. RESULTS: Recent interest in different plant has focused on isolating and identifying of different phytoconstituents that exhibit Phospholipase A2 activity and other venom enzyme neutralizing ability. In this support convincing evidence in experimental animal models are available. CONCLUSION: Secondary metabolites are naturally present, have no side effect, are stable for a long time, can be easily stored, and can neutralize a wide range of snake enzymes, such as phospholipase A2, hyaluronidase, protease, L-amino acid oxidase, 5′nucleotidase, etc. The current review presents a compilation of important plant secondary metabolites that are effective against snake venom due to enzyme neutralization. the Korean Pharmacopuncture Institute (KPI) 2017-09 2017-09-30 /pmc/articles/PMC5633669/ /pubmed/30087793 http://dx.doi.org/10.3831/KPI.2017.20.020 Text en © 2017 Korean Pharmacopuncture Institute This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Singh, Pushpendra Yasir, Mohammad Hazarika, Risha Sugunan, Sunisha Shrivastava, Rahul A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants |
title | A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants |
title_full | A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants |
title_fullStr | A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants |
title_full_unstemmed | A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants |
title_short | A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants |
title_sort | review on venom enzymes neutralizing ability of secondary metabolites from medicinal plants |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633669/ https://www.ncbi.nlm.nih.gov/pubmed/30087793 http://dx.doi.org/10.3831/KPI.2017.20.020 |
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