Speculative Considerations about Some Cardiology Enigmas

BACKGROUND: Enigmas often lead to hypotheses and speculations. For this reason, especially for the sake of the reader’s motivation, we opted for the plain discussion of some cardiology enigmas. OBJECTIVE: The present text was aimed to discuss speculatively some cardiology enigmas. METHOD: Text was freely designed in the context of coronary artery and heart valve diseases. RESULTS: The results were presented as the combination enigma/hypothesis. 1) The absence of arteriosclerosis in intramyocardial coronary arteries/ endothelium-myocardial interaction (crosstalk); 2) The unique and always confirmed superior evolution of the internal thoracic artery as coronary graft/ higher NO basal release 3) The prophylactic left internal thoracic artery graft in mildly-stenosed coronary lesions/need of more accurate functional imaging techniques; 4) The high incidence of perioperative atrial fibrillation in patients with coronary artery disease/atrial ischemia associated to left circumflex coronary lesions; 5) The handling of disease-free saphenous vein grafts at the time of re-operation/biological serendipity with graft vein segments; 6) The possible aortic stenosis protection against coronary artery disease/ endothelium myocardium interaction (crosstalk) improving NO release. CONCLUSION: The discussed topics associated with their respective speculative hypothesis remain as enigmas, but would become motivations for investigations