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Interval exercise increases angiogenic cell function in postmenopausal women

INTRODUCTION: Exercise can help to negate the increased cardiovascular disease risk observed in women after the menopausal transition. This study sought to determine whether interval or continuous exercise has differential effects on endothelial function and circulating angiogenic cell (CAC) number...

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Autores principales: Harris, Emma, Rakobowchuk, Mark, Birch, Karen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633736/
https://www.ncbi.nlm.nih.gov/pubmed/29021911
http://dx.doi.org/10.1136/bmjsem-2017-000248
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author Harris, Emma
Rakobowchuk, Mark
Birch, Karen M
author_facet Harris, Emma
Rakobowchuk, Mark
Birch, Karen M
author_sort Harris, Emma
collection PubMed
description INTRODUCTION: Exercise can help to negate the increased cardiovascular disease risk observed in women after the menopausal transition. This study sought to determine whether interval or continuous exercise has differential effects on endothelial function and circulating angiogenic cell (CAC) number and function in postmenopausal women. METHODS: Fifteen healthy postmenopausal women completed a 30 min acute moderate-intensity continuous (CON) and interval exercise (MOD-INT) session on a cycle ergometer on separate days. Nine participants completed a further single 30 min acute heavy-intensity interval (HEAVY-INT) exercise session. Brachial artery flow-mediated dilation (FMD) was assessed pre-exercise and 15 min post-exercise session. CAC number and colony-forming capacity in vitro were assessed post exercise and compared with resting levels. RESULTS: FMD and CAC number did not change post exercise regardless of exercise type (p>0.05). However, the number (mean±SD) of colony-forming units (CFUs) increased from visit 1 (12±10 CFUs/well) to post MOD-INT (32±30 CFUs/well) and post HEAVY-INT (38±23 CFUs/well) but not post CON (13±14 CFUs/well). CONCLUSION: A single session of interval exercise is more effective than a continuous exercise session for increasing the intercellular communication of CACs, regardless of exercise intensity. The enhanced ability of CACs to form colonies may reflect an increased number and/or function of angiogenic T-cells. The repeated exertions to higher work rates during interval exercise may explain this response. Repeated exercise sessions might be required to improve FMD in postmenopausal women.
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spelling pubmed-56337362017-10-11 Interval exercise increases angiogenic cell function in postmenopausal women Harris, Emma Rakobowchuk, Mark Birch, Karen M BMJ Open Sport Exerc Med Original Article INTRODUCTION: Exercise can help to negate the increased cardiovascular disease risk observed in women after the menopausal transition. This study sought to determine whether interval or continuous exercise has differential effects on endothelial function and circulating angiogenic cell (CAC) number and function in postmenopausal women. METHODS: Fifteen healthy postmenopausal women completed a 30 min acute moderate-intensity continuous (CON) and interval exercise (MOD-INT) session on a cycle ergometer on separate days. Nine participants completed a further single 30 min acute heavy-intensity interval (HEAVY-INT) exercise session. Brachial artery flow-mediated dilation (FMD) was assessed pre-exercise and 15 min post-exercise session. CAC number and colony-forming capacity in vitro were assessed post exercise and compared with resting levels. RESULTS: FMD and CAC number did not change post exercise regardless of exercise type (p>0.05). However, the number (mean±SD) of colony-forming units (CFUs) increased from visit 1 (12±10 CFUs/well) to post MOD-INT (32±30 CFUs/well) and post HEAVY-INT (38±23 CFUs/well) but not post CON (13±14 CFUs/well). CONCLUSION: A single session of interval exercise is more effective than a continuous exercise session for increasing the intercellular communication of CACs, regardless of exercise intensity. The enhanced ability of CACs to form colonies may reflect an increased number and/or function of angiogenic T-cells. The repeated exertions to higher work rates during interval exercise may explain this response. Repeated exercise sessions might be required to improve FMD in postmenopausal women. BMJ Publishing Group 2017-08-06 /pmc/articles/PMC5633736/ /pubmed/29021911 http://dx.doi.org/10.1136/bmjsem-2017-000248 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Harris, Emma
Rakobowchuk, Mark
Birch, Karen M
Interval exercise increases angiogenic cell function in postmenopausal women
title Interval exercise increases angiogenic cell function in postmenopausal women
title_full Interval exercise increases angiogenic cell function in postmenopausal women
title_fullStr Interval exercise increases angiogenic cell function in postmenopausal women
title_full_unstemmed Interval exercise increases angiogenic cell function in postmenopausal women
title_short Interval exercise increases angiogenic cell function in postmenopausal women
title_sort interval exercise increases angiogenic cell function in postmenopausal women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633736/
https://www.ncbi.nlm.nih.gov/pubmed/29021911
http://dx.doi.org/10.1136/bmjsem-2017-000248
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