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Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand

OBJECTIVES: The aim of this study is to compare the cost and benefit of four different cervical cancer screening strategies involving primary HPV 16/18 genotyping, hrHPV testing alone and cytology for detecting CIN2 +. METHODS: Economical analysis using Markov modeling approach to combine the epidem...

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Autores principales: Termrungruanglert, Wichai, Khemapech, Nipon, Tantitamit, Tanitra, Sangrajrang, Suleeporn, Havanond, Piyalamporn, Laowahutanont, Piyawat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633754/
https://www.ncbi.nlm.nih.gov/pubmed/29034308
http://dx.doi.org/10.1016/j.gore.2017.09.007
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author Termrungruanglert, Wichai
Khemapech, Nipon
Tantitamit, Tanitra
Sangrajrang, Suleeporn
Havanond, Piyalamporn
Laowahutanont, Piyawat
author_facet Termrungruanglert, Wichai
Khemapech, Nipon
Tantitamit, Tanitra
Sangrajrang, Suleeporn
Havanond, Piyalamporn
Laowahutanont, Piyawat
author_sort Termrungruanglert, Wichai
collection PubMed
description OBJECTIVES: The aim of this study is to compare the cost and benefit of four different cervical cancer screening strategies involving primary HPV 16/18 genotyping, hrHPV testing alone and cytology for detecting CIN2 +. METHODS: Economical analysis using Markov modeling approach to combine the epidemiological data from current population-based study of The National Cancer Institute of Thailand. A cohort of 100,000 hypothetical female population age 30–65 years was simulated in each strategy. The compared strategies are HPV 16/18 genotyping with reflexed cytology, hrHPV testing alone followed by colposcopy, Papanicolaou standard cytology and liquid based cytology followed by colposcopy. The interval of screening was 5 years' interval. The main outcomes were defined as a number of CIN2 + cases and cost per 100,000 women screening over 35 years. RESULTS: Model predictions indicated that, the most cost-effectiveness strategy is hrHPV testing alone by reducing cost and also increase CIN2 + detection rate. It identify an additional 130 cases and decrease cost by 46,950,840 THB (1,394,441 USD) per 100,000 women screened when compared to HPV 16/18 genotyping. Compared with cytology, hrHPV testing decrease cost by 51,279,781 THB (1,523,011 USD) and detected more 506 cases of CIN2 +. From sensitivity analysis, the cost of HPV testing, cost of colposcopy, incidence of HPV infection and sensitivity of cytology may affect the results. (1 USD = 33.67 Baht). CONCLUSION: The results of this cost-effectiveness analysis support the full scale implementation of HPV testing as a primary cervical cancer screening in Thailand.
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spelling pubmed-56337542017-10-13 Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand Termrungruanglert, Wichai Khemapech, Nipon Tantitamit, Tanitra Sangrajrang, Suleeporn Havanond, Piyalamporn Laowahutanont, Piyawat Gynecol Oncol Rep Virtual Special Section on Gynecologic Cancers in Resource-constrained Countries; Edited by Linus Chuang OBJECTIVES: The aim of this study is to compare the cost and benefit of four different cervical cancer screening strategies involving primary HPV 16/18 genotyping, hrHPV testing alone and cytology for detecting CIN2 +. METHODS: Economical analysis using Markov modeling approach to combine the epidemiological data from current population-based study of The National Cancer Institute of Thailand. A cohort of 100,000 hypothetical female population age 30–65 years was simulated in each strategy. The compared strategies are HPV 16/18 genotyping with reflexed cytology, hrHPV testing alone followed by colposcopy, Papanicolaou standard cytology and liquid based cytology followed by colposcopy. The interval of screening was 5 years' interval. The main outcomes were defined as a number of CIN2 + cases and cost per 100,000 women screening over 35 years. RESULTS: Model predictions indicated that, the most cost-effectiveness strategy is hrHPV testing alone by reducing cost and also increase CIN2 + detection rate. It identify an additional 130 cases and decrease cost by 46,950,840 THB (1,394,441 USD) per 100,000 women screened when compared to HPV 16/18 genotyping. Compared with cytology, hrHPV testing decrease cost by 51,279,781 THB (1,523,011 USD) and detected more 506 cases of CIN2 +. From sensitivity analysis, the cost of HPV testing, cost of colposcopy, incidence of HPV infection and sensitivity of cytology may affect the results. (1 USD = 33.67 Baht). CONCLUSION: The results of this cost-effectiveness analysis support the full scale implementation of HPV testing as a primary cervical cancer screening in Thailand. Elsevier 2017-09-28 /pmc/articles/PMC5633754/ /pubmed/29034308 http://dx.doi.org/10.1016/j.gore.2017.09.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Virtual Special Section on Gynecologic Cancers in Resource-constrained Countries; Edited by Linus Chuang
Termrungruanglert, Wichai
Khemapech, Nipon
Tantitamit, Tanitra
Sangrajrang, Suleeporn
Havanond, Piyalamporn
Laowahutanont, Piyawat
Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand
title Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand
title_full Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand
title_fullStr Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand
title_full_unstemmed Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand
title_short Cost-effectiveness analysis study of HPV testing as a primary cervical cancer screening in Thailand
title_sort cost-effectiveness analysis study of hpv testing as a primary cervical cancer screening in thailand
topic Virtual Special Section on Gynecologic Cancers in Resource-constrained Countries; Edited by Linus Chuang
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633754/
https://www.ncbi.nlm.nih.gov/pubmed/29034308
http://dx.doi.org/10.1016/j.gore.2017.09.007
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