Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging

The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([(11)C]CO) from cyclotron-produced carbon-11 carbon dioxide ([(11)C]CO(2)) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [(11)C]CO from [(11)C]CO(2). Pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Anders, David A., Bongarzone, Salvatore, Fortt, Robin, Gee, Antony D., Long, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633808/
https://www.ncbi.nlm.nih.gov/pubmed/28234400
http://dx.doi.org/10.1039/c7cc00319f
_version_ 1783269958103334912
author Anders, David A.
Bongarzone, Salvatore
Fortt, Robin
Gee, Antony D.
Long, Nicholas J.
author_facet Anders, David A.
Bongarzone, Salvatore
Fortt, Robin
Gee, Antony D.
Long, Nicholas J.
author_sort Anders, David A.
collection PubMed
description The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([(11)C]CO) from cyclotron-produced carbon-11 carbon dioxide ([(11)C]CO(2)) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [(11)C]CO from [(11)C]CO(2). Produced [(11)C]CO was subsequently converted to [(11)C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.
format Online
Article
Text
id pubmed-5633808
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-56338082017-10-27 Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging Anders, David A. Bongarzone, Salvatore Fortt, Robin Gee, Antony D. Long, Nicholas J. Chem Commun (Camb) Chemistry The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([(11)C]CO) from cyclotron-produced carbon-11 carbon dioxide ([(11)C]CO(2)) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [(11)C]CO from [(11)C]CO(2). Produced [(11)C]CO was subsequently converted to [(11)C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%. Royal Society of Chemistry 2017-03-11 2017-02-24 /pmc/articles/PMC5633808/ /pubmed/28234400 http://dx.doi.org/10.1039/c7cc00319f Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Anders, David A.
Bongarzone, Salvatore
Fortt, Robin
Gee, Antony D.
Long, Nicholas J.
Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging
title Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging
title_full Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging
title_fullStr Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging
title_full_unstemmed Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging
title_short Electrochemical [(11)C]CO(2) to [(11)C]CO conversion for PET imaging
title_sort electrochemical [(11)c]co(2) to [(11)c]co conversion for pet imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633808/
https://www.ncbi.nlm.nih.gov/pubmed/28234400
http://dx.doi.org/10.1039/c7cc00319f
work_keys_str_mv AT andersdavida electrochemical11cco2to11ccoconversionforpetimaging
AT bongarzonesalvatore electrochemical11cco2to11ccoconversionforpetimaging
AT forttrobin electrochemical11cco2to11ccoconversionforpetimaging
AT geeantonyd electrochemical11cco2to11ccoconversionforpetimaging
AT longnicholasj electrochemical11cco2to11ccoconversionforpetimaging

Ejemplares similares