Function-Oriented Studies Targeting Pectenotoxin 2: Synthesis of the GH-Ring System and a Structurally Simplified Macrolactone

[Image: see text] A chemical foundation for function-oriented studies of pectenotoxin 2 (PTX2) is described. A synthesis of the bicyclic GH-system, and the design and synthesis of a PTX2-analogue, is presented. While maintaining critical features for actin binding, and lacking the Achilles’ heel for...

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Detalles Bibliográficos
Autores principales: O’Rourke, Natasha F., A, Mu, Higgs, Henry N., Eastman, Alan, Micalizio, Glenn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633828/
https://www.ncbi.nlm.nih.gov/pubmed/28901150
http://dx.doi.org/10.1021/acs.orglett.7b02435

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