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Characterization of lens based photoacoustic imaging system()

Some of the challenges in translating photoacoustic (PA) imaging to clinical applications includes limited view of the target tissue, low signal to noise ratio and the high cost of developing real-time systems. Acoustic lens based PA imaging systems, also known as PA cameras are a potential alternat...

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Autores principales: Francis, Kalloor Joseph, Chinni, Bhargava, Channappayya, Sumohana S., Pachamuthu, Rajalakshmi, Dogra, Vikram S., Rao, Navalgund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633851/
https://www.ncbi.nlm.nih.gov/pubmed/29034167
http://dx.doi.org/10.1016/j.pacs.2017.09.003
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author Francis, Kalloor Joseph
Chinni, Bhargava
Channappayya, Sumohana S.
Pachamuthu, Rajalakshmi
Dogra, Vikram S.
Rao, Navalgund
author_facet Francis, Kalloor Joseph
Chinni, Bhargava
Channappayya, Sumohana S.
Pachamuthu, Rajalakshmi
Dogra, Vikram S.
Rao, Navalgund
author_sort Francis, Kalloor Joseph
collection PubMed
description Some of the challenges in translating photoacoustic (PA) imaging to clinical applications includes limited view of the target tissue, low signal to noise ratio and the high cost of developing real-time systems. Acoustic lens based PA imaging systems, also known as PA cameras are a potential alternative to conventional imaging systems in these scenarios. The 3D focusing action of lens enables real-time C-scan imaging with a 2D transducer array. In this paper, we model the underlying physics in a PA camera in the mathematical framework of an imaging system and derive a closed form expression for the point spread function (PSF). Experimental verification follows including the details on how to design and fabricate the lens inexpensively. The system PSF is evaluated over a 3D volume that can be imaged by this PA camera. Its utility is demonstrated by imaging phantom and an ex vivo human prostate tissue sample.
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spelling pubmed-56338512017-10-13 Characterization of lens based photoacoustic imaging system() Francis, Kalloor Joseph Chinni, Bhargava Channappayya, Sumohana S. Pachamuthu, Rajalakshmi Dogra, Vikram S. Rao, Navalgund Photoacoustics Research Article Some of the challenges in translating photoacoustic (PA) imaging to clinical applications includes limited view of the target tissue, low signal to noise ratio and the high cost of developing real-time systems. Acoustic lens based PA imaging systems, also known as PA cameras are a potential alternative to conventional imaging systems in these scenarios. The 3D focusing action of lens enables real-time C-scan imaging with a 2D transducer array. In this paper, we model the underlying physics in a PA camera in the mathematical framework of an imaging system and derive a closed form expression for the point spread function (PSF). Experimental verification follows including the details on how to design and fabricate the lens inexpensively. The system PSF is evaluated over a 3D volume that can be imaged by this PA camera. Its utility is demonstrated by imaging phantom and an ex vivo human prostate tissue sample. Elsevier 2017-09-23 /pmc/articles/PMC5633851/ /pubmed/29034167 http://dx.doi.org/10.1016/j.pacs.2017.09.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Francis, Kalloor Joseph
Chinni, Bhargava
Channappayya, Sumohana S.
Pachamuthu, Rajalakshmi
Dogra, Vikram S.
Rao, Navalgund
Characterization of lens based photoacoustic imaging system()
title Characterization of lens based photoacoustic imaging system()
title_full Characterization of lens based photoacoustic imaging system()
title_fullStr Characterization of lens based photoacoustic imaging system()
title_full_unstemmed Characterization of lens based photoacoustic imaging system()
title_short Characterization of lens based photoacoustic imaging system()
title_sort characterization of lens based photoacoustic imaging system()
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633851/
https://www.ncbi.nlm.nih.gov/pubmed/29034167
http://dx.doi.org/10.1016/j.pacs.2017.09.003
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