Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway

BACKGROUND: Prostate cancer (PCa) is one of the most frequent tumors and leading cause of cancer deaths among males worldwide. The majority of deaths are due to recurrence and subsequent development of the metastatic cancer. Although loss or dislocalization of polarity proteins has been implicated i...

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Detalles Bibliográficos
Autores principales: Zhou, Pei-Jie, Xue, Wei, Peng, Jinliang, Wang, Yanqing, Wei, Lianzi, Yang, Ziqiang, Zhu, Helen He, Fang, Yu-Xiang, Gao, Wei-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633884/
https://www.ncbi.nlm.nih.gov/pubmed/29017577
http://dx.doi.org/10.1186/s13046-017-0609-y

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