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Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4

BACKGROUND: Human cancer cells often exhibit impaired IGF2 expression and the underlying mechanisms are multifaceted and complex. Besides the well-known imprinting control region IGF2/H19-ICR, the involvement of a differentially methylated region in the promoter P0 of IGF2 gene (IGF2-DMR0) has been...

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Detalles Bibliográficos
Autores principales:	Schagdarsurengin, Undraga, Lammert, Angela, Schunk, Natalie, Sheridan, Diana, Gattenloehner, Stefan, Steger, Klaus, Wagenlehner, Florian, Dansranjavin, Temuujin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633889/ https://www.ncbi.nlm.nih.gov/pubmed/29017567 http://dx.doi.org/10.1186/s12964-017-0197-7

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