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Whole genome DNA methylation sequencing of the chicken retina, cornea and brain

Whole genome bisulfite sequencing (WGBS) analysis of DNA methylation uses massively parallel next generation sequencing technology to characterize global epigenetic patterns and fluctuations throughout a range of tissue samples. Development of the vertebrate retina is thought to involve extensive ep...

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Autores principales: Lee, Isac, Rasoul, Bejan A., Holub, Ashton S., Lejeune, Alannah, Enke, Raymond A., Timp, Winston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634322/
https://www.ncbi.nlm.nih.gov/pubmed/28994822
http://dx.doi.org/10.1038/sdata.2017.148
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author Lee, Isac
Rasoul, Bejan A.
Holub, Ashton S.
Lejeune, Alannah
Enke, Raymond A.
Timp, Winston
author_facet Lee, Isac
Rasoul, Bejan A.
Holub, Ashton S.
Lejeune, Alannah
Enke, Raymond A.
Timp, Winston
author_sort Lee, Isac
collection PubMed
description Whole genome bisulfite sequencing (WGBS) analysis of DNA methylation uses massively parallel next generation sequencing technology to characterize global epigenetic patterns and fluctuations throughout a range of tissue samples. Development of the vertebrate retina is thought to involve extensive epigenetic reprogramming during embryogenesis. The chicken embryo (Gallus gallus) is a classic model system for studying developmental biology and retinogenesis, however, there are currently no publicly available data sets describing the developing chicken retinal methylome. Here we used Illumina WGBS analysis to characterize genome-wide patterns of DNA methylation in the developing chicken retina as well as cornea and brain in an effort to further our understanding of retina-specific epigenetic regulation. These data will be valuable to the vision research community for correlating global changes in DNA methylation to differential gene expression between ocular and neural tissues during critical developmental time points of retinogenesis in the chicken retina.
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spelling pubmed-56343222017-10-11 Whole genome DNA methylation sequencing of the chicken retina, cornea and brain Lee, Isac Rasoul, Bejan A. Holub, Ashton S. Lejeune, Alannah Enke, Raymond A. Timp, Winston Sci Data Data Descriptor Whole genome bisulfite sequencing (WGBS) analysis of DNA methylation uses massively parallel next generation sequencing technology to characterize global epigenetic patterns and fluctuations throughout a range of tissue samples. Development of the vertebrate retina is thought to involve extensive epigenetic reprogramming during embryogenesis. The chicken embryo (Gallus gallus) is a classic model system for studying developmental biology and retinogenesis, however, there are currently no publicly available data sets describing the developing chicken retinal methylome. Here we used Illumina WGBS analysis to characterize genome-wide patterns of DNA methylation in the developing chicken retina as well as cornea and brain in an effort to further our understanding of retina-specific epigenetic regulation. These data will be valuable to the vision research community for correlating global changes in DNA methylation to differential gene expression between ocular and neural tissues during critical developmental time points of retinogenesis in the chicken retina. Nature Publishing Group 2017-10-10 /pmc/articles/PMC5634322/ /pubmed/28994822 http://dx.doi.org/10.1038/sdata.2017.148 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.
spellingShingle Data Descriptor
Lee, Isac
Rasoul, Bejan A.
Holub, Ashton S.
Lejeune, Alannah
Enke, Raymond A.
Timp, Winston
Whole genome DNA methylation sequencing of the chicken retina, cornea and brain
title Whole genome DNA methylation sequencing of the chicken retina, cornea and brain
title_full Whole genome DNA methylation sequencing of the chicken retina, cornea and brain
title_fullStr Whole genome DNA methylation sequencing of the chicken retina, cornea and brain
title_full_unstemmed Whole genome DNA methylation sequencing of the chicken retina, cornea and brain
title_short Whole genome DNA methylation sequencing of the chicken retina, cornea and brain
title_sort whole genome dna methylation sequencing of the chicken retina, cornea and brain
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634322/
https://www.ncbi.nlm.nih.gov/pubmed/28994822
http://dx.doi.org/10.1038/sdata.2017.148
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