Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice

The hippocampus has been the target of stem cell transplantations in preclinical studies focused on Alzheimer's disease, with results showing improvements in histological and behavioral outcomes. The corpus callosum is another structure that is affected early in Alzheimer's disease. Theref...

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Autores principales: McGinley, Lisa M., Kashlan, Osama N., Chen, Kevin S., Bruno, Elizabeth S., Hayes, John M., Backus, Carey, Feldman, Seth, Kashlan, Bader N., Johe, Karl, Feldman, Eva L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634341/
https://www.ncbi.nlm.nih.gov/pubmed/29046883
http://dx.doi.org/10.1002/acn3.443
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author McGinley, Lisa M.
Kashlan, Osama N.
Chen, Kevin S.
Bruno, Elizabeth S.
Hayes, John M.
Backus, Carey
Feldman, Seth
Kashlan, Bader N.
Johe, Karl
Feldman, Eva L.
author_facet McGinley, Lisa M.
Kashlan, Osama N.
Chen, Kevin S.
Bruno, Elizabeth S.
Hayes, John M.
Backus, Carey
Feldman, Seth
Kashlan, Bader N.
Johe, Karl
Feldman, Eva L.
author_sort McGinley, Lisa M.
collection PubMed
description The hippocampus has been the target of stem cell transplantations in preclinical studies focused on Alzheimer's disease, with results showing improvements in histological and behavioral outcomes. The corpus callosum is another structure that is affected early in Alzheimer's disease. Therefore, we hypothesize that this structure is a novel target for human neural stem cell transplantation in transgenic Alzheimer's disease mouse models. This study demonstrates the feasibility of targeting the corpus callosum and identifies an effective immunosuppression regimen for transplanted neural stem cell survival. These results support further preclinical development of the corpus callosum as a therapeutic target in Alzheimer's disease.
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spelling pubmed-56343412017-10-18 Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice McGinley, Lisa M. Kashlan, Osama N. Chen, Kevin S. Bruno, Elizabeth S. Hayes, John M. Backus, Carey Feldman, Seth Kashlan, Bader N. Johe, Karl Feldman, Eva L. Ann Clin Transl Neurol Brief Communications The hippocampus has been the target of stem cell transplantations in preclinical studies focused on Alzheimer's disease, with results showing improvements in histological and behavioral outcomes. The corpus callosum is another structure that is affected early in Alzheimer's disease. Therefore, we hypothesize that this structure is a novel target for human neural stem cell transplantation in transgenic Alzheimer's disease mouse models. This study demonstrates the feasibility of targeting the corpus callosum and identifies an effective immunosuppression regimen for transplanted neural stem cell survival. These results support further preclinical development of the corpus callosum as a therapeutic target in Alzheimer's disease. John Wiley and Sons Inc. 2017-08-18 /pmc/articles/PMC5634341/ /pubmed/29046883 http://dx.doi.org/10.1002/acn3.443 Text en © 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
McGinley, Lisa M.
Kashlan, Osama N.
Chen, Kevin S.
Bruno, Elizabeth S.
Hayes, John M.
Backus, Carey
Feldman, Seth
Kashlan, Bader N.
Johe, Karl
Feldman, Eva L.
Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice
title Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice
title_full Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice
title_fullStr Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice
title_full_unstemmed Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice
title_short Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice
title_sort human neural stem cell transplantation into the corpus callosum of alzheimer's mice
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634341/
https://www.ncbi.nlm.nih.gov/pubmed/29046883
http://dx.doi.org/10.1002/acn3.443
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