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Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
PURPOSE: We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS: Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX E...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634352/ https://www.ncbi.nlm.nih.gov/pubmed/28986595 http://dx.doi.org/10.1167/iovs.17-22506 |
Sumario: | PURPOSE: We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS: Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 [Formula: see text] 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 [Formula: see text] 6 mm scan. RESULTS: A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm(2) for the 3 [Formula: see text] 3, 6 [Formula: see text] 6, and 12 [Formula: see text] 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 [Formula: see text] 3 vs. 6 [Formula: see text] 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm(2) for the 6 [Formula: see text] 6, 9 [Formula: see text] 9, and 12 [Formula: see text] 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 [Formula: see text] 6 vs. 9 [Formula: see text] 9 mm; P = 0.553, 6 [Formula: see text] 6 vs. 12 [Formula: see text] 12 mm; P = 0.654, 9 [Formula: see text] 9 vs. 12 [Formula: see text] 12 mm). CONCLUSIONS: The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses. |
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