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Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration

PURPOSE: We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS: Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX E...

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Autores principales: Zheng, Fang, Zhang, Qinqin, Motulsky, Elie H., de Oliveira Dias, João Rafael, Chen, Chieh-Li, Chu, Zhongdi, Miller, Andrew R., Feuer, William, Gregori, Giovanni, Kubach, Sophie, Durbin, Mary K., Wang, Ruikang K., Rosenfeld, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634352/
https://www.ncbi.nlm.nih.gov/pubmed/28986595
http://dx.doi.org/10.1167/iovs.17-22506
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author Zheng, Fang
Zhang, Qinqin
Motulsky, Elie H.
de Oliveira Dias, João Rafael
Chen, Chieh-Li
Chu, Zhongdi
Miller, Andrew R.
Feuer, William
Gregori, Giovanni
Kubach, Sophie
Durbin, Mary K.
Wang, Ruikang K.
Rosenfeld, Philip J.
author_facet Zheng, Fang
Zhang, Qinqin
Motulsky, Elie H.
de Oliveira Dias, João Rafael
Chen, Chieh-Li
Chu, Zhongdi
Miller, Andrew R.
Feuer, William
Gregori, Giovanni
Kubach, Sophie
Durbin, Mary K.
Wang, Ruikang K.
Rosenfeld, Philip J.
author_sort Zheng, Fang
collection PubMed
description PURPOSE: We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS: Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 [Formula: see text] 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 [Formula: see text] 6 mm scan. RESULTS: A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm(2) for the 3 [Formula: see text] 3, 6 [Formula: see text] 6, and 12 [Formula: see text] 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 [Formula: see text] 3 vs. 6 [Formula: see text] 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm(2) for the 6 [Formula: see text] 6, 9 [Formula: see text] 9, and 12 [Formula: see text] 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 [Formula: see text] 6 vs. 9 [Formula: see text] 9 mm; P = 0.553, 6 [Formula: see text] 6 vs. 12 [Formula: see text] 12 mm; P = 0.654, 9 [Formula: see text] 9 vs. 12 [Formula: see text] 12 mm). CONCLUSIONS: The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.
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spelling pubmed-56343522017-10-18 Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration Zheng, Fang Zhang, Qinqin Motulsky, Elie H. de Oliveira Dias, João Rafael Chen, Chieh-Li Chu, Zhongdi Miller, Andrew R. Feuer, William Gregori, Giovanni Kubach, Sophie Durbin, Mary K. Wang, Ruikang K. Rosenfeld, Philip J. Invest Ophthalmol Vis Sci Retina PURPOSE: We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. METHODS: Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 [Formula: see text] 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 [Formula: see text] 6 mm scan. RESULTS: A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm(2) for the 3 [Formula: see text] 3, 6 [Formula: see text] 6, and 12 [Formula: see text] 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 [Formula: see text] 3 vs. 6 [Formula: see text] 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm(2) for the 6 [Formula: see text] 6, 9 [Formula: see text] 9, and 12 [Formula: see text] 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 [Formula: see text] 6 vs. 9 [Formula: see text] 9 mm; P = 0.553, 6 [Formula: see text] 6 vs. 12 [Formula: see text] 12 mm; P = 0.654, 9 [Formula: see text] 9 vs. 12 [Formula: see text] 12 mm). CONCLUSIONS: The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses. The Association for Research in Vision and Ophthalmology 2017-10 /pmc/articles/PMC5634352/ /pubmed/28986595 http://dx.doi.org/10.1167/iovs.17-22506 Text en Copyright 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Retina
Zheng, Fang
Zhang, Qinqin
Motulsky, Elie H.
de Oliveira Dias, João Rafael
Chen, Chieh-Li
Chu, Zhongdi
Miller, Andrew R.
Feuer, William
Gregori, Giovanni
Kubach, Sophie
Durbin, Mary K.
Wang, Ruikang K.
Rosenfeld, Philip J.
Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
title Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
title_full Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
title_fullStr Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
title_full_unstemmed Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
title_short Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration
title_sort comparison of neovascular lesion area measurements from different swept-source oct angiographic scan patterns in age-related macular degeneration
topic Retina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634352/
https://www.ncbi.nlm.nih.gov/pubmed/28986595
http://dx.doi.org/10.1167/iovs.17-22506
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