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Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion

The highly invasive nature of glioblastoma is one of the most significant problems regarding the treatment of this tumor. Diamond nanoparticles (ND), graphite nanoparticles (NG), and graphene oxide nanoplatelets (nGO) have been explored for their biomedical applications, especially for drug delivery...

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Autores principales: Wierzbicki, Mateusz, Jaworski, Sławomir, Kutwin, Marta, Grodzik, Marta, Strojny, Barbara, Kurantowicz, Natalia, Zdunek, Krzysztof, Chodun, Rafał, Chwalibog, André, Sawosz, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634373/
https://www.ncbi.nlm.nih.gov/pubmed/29042773
http://dx.doi.org/10.2147/IJN.S146193
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author Wierzbicki, Mateusz
Jaworski, Sławomir
Kutwin, Marta
Grodzik, Marta
Strojny, Barbara
Kurantowicz, Natalia
Zdunek, Krzysztof
Chodun, Rafał
Chwalibog, André
Sawosz, Ewa
author_facet Wierzbicki, Mateusz
Jaworski, Sławomir
Kutwin, Marta
Grodzik, Marta
Strojny, Barbara
Kurantowicz, Natalia
Zdunek, Krzysztof
Chodun, Rafał
Chwalibog, André
Sawosz, Ewa
author_sort Wierzbicki, Mateusz
collection PubMed
description The highly invasive nature of glioblastoma is one of the most significant problems regarding the treatment of this tumor. Diamond nanoparticles (ND), graphite nanoparticles (NG), and graphene oxide nanoplatelets (nGO) have been explored for their biomedical applications, especially for drug delivery. The objective of this research was to assess changes in the adhesion, migration, and invasiveness of two glioblastoma cell lines, U87 and U118, after ND, NG, and nGO treatment. All treatments affected the cell surface structure, adhesion-dependent EGFR/AKT/mTOR, and β-catenin signaling pathways, decreasing the migration and invasiveness of both glioblastoma cell lines. The examined nanoparticles did not show strong toxicity but effectively deregulated cell migration. ND was effectively taken up by cells, whereas nGO and NG strongly interacted with the cell surface. These results indicate that nanoparticles could be used in biomedical applications as a low toxicity active compound for glioblastoma treatment.
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spelling pubmed-56343732017-10-17 Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion Wierzbicki, Mateusz Jaworski, Sławomir Kutwin, Marta Grodzik, Marta Strojny, Barbara Kurantowicz, Natalia Zdunek, Krzysztof Chodun, Rafał Chwalibog, André Sawosz, Ewa Int J Nanomedicine Original Research The highly invasive nature of glioblastoma is one of the most significant problems regarding the treatment of this tumor. Diamond nanoparticles (ND), graphite nanoparticles (NG), and graphene oxide nanoplatelets (nGO) have been explored for their biomedical applications, especially for drug delivery. The objective of this research was to assess changes in the adhesion, migration, and invasiveness of two glioblastoma cell lines, U87 and U118, after ND, NG, and nGO treatment. All treatments affected the cell surface structure, adhesion-dependent EGFR/AKT/mTOR, and β-catenin signaling pathways, decreasing the migration and invasiveness of both glioblastoma cell lines. The examined nanoparticles did not show strong toxicity but effectively deregulated cell migration. ND was effectively taken up by cells, whereas nGO and NG strongly interacted with the cell surface. These results indicate that nanoparticles could be used in biomedical applications as a low toxicity active compound for glioblastoma treatment. Dove Medical Press 2017-10-04 /pmc/articles/PMC5634373/ /pubmed/29042773 http://dx.doi.org/10.2147/IJN.S146193 Text en © 2017 Wierzbicki et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wierzbicki, Mateusz
Jaworski, Sławomir
Kutwin, Marta
Grodzik, Marta
Strojny, Barbara
Kurantowicz, Natalia
Zdunek, Krzysztof
Chodun, Rafał
Chwalibog, André
Sawosz, Ewa
Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion
title Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion
title_full Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion
title_fullStr Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion
title_full_unstemmed Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion
title_short Diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion
title_sort diamond, graphite, and graphene oxide nanoparticles decrease migration and invasiveness in glioblastoma cell lines by impairing extracellular adhesion
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634373/
https://www.ncbi.nlm.nih.gov/pubmed/29042773
http://dx.doi.org/10.2147/IJN.S146193
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