Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells

In this study, through covalent conjugation and lipid material entrapment, a combined modification strategy was established for effective delivery of small interfering RNA (siRNA). Single strands of siRNA targeting to BRAF(V600E) gene (siMB3) conjugated with cRGD peptide at 3′-terminus or 5′-terminu...

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Detalles Bibliográficos
Autores principales: Zhou, Zhaoxiu, Liu, Shuang, Zhang, Yanfen, Yang, Xiantao, Ma, Yuan, Guan, Zhu, Wu, Yun, Zhang, Lihe, Yang, Zhenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634379/
https://www.ncbi.nlm.nih.gov/pubmed/29042774
http://dx.doi.org/10.2147/IJN.S136726

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