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Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst...

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Autores principales: Din, Fakhar ud, Aman, Waqar, Ullah, Izhar, Qureshi, Omer Salman, Mustapha, Omer, Shafique, Shumaila, Zeb, Alam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634382/
https://www.ncbi.nlm.nih.gov/pubmed/29042776
http://dx.doi.org/10.2147/IJN.S146315
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author Din, Fakhar ud
Aman, Waqar
Ullah, Izhar
Qureshi, Omer Salman
Mustapha, Omer
Shafique, Shumaila
Zeb, Alam
author_facet Din, Fakhar ud
Aman, Waqar
Ullah, Izhar
Qureshi, Omer Salman
Mustapha, Omer
Shafique, Shumaila
Zeb, Alam
author_sort Din, Fakhar ud
collection PubMed
description Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damaging the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site. A number of nanocarriers have been developed; however, only a few of them are clinically approved for the delivery of antitumor drugs for their intended actions at the targeted sites. The present review is divided into three main parts: first part presents introduction of various nanocarriers and their relevance in the delivery of anticancer drugs, second part encompasses targeting mechanisms and surface functionalization on nanocarriers and third part covers the description of selected tumors, including breast, lungs, colorectal and pancreatic tumors, and applications of relative nanocarriers in these tumors. This review increases the understanding of tumor treatment with the promising use of nanotechnology.
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spelling pubmed-56343822017-10-17 Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors Din, Fakhar ud Aman, Waqar Ullah, Izhar Qureshi, Omer Salman Mustapha, Omer Shafique, Shumaila Zeb, Alam Int J Nanomedicine Review Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used to circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release and damaging the normal cells. Nanocarriers improve the bioavailability and therapeutic efficiency of antitumor drugs, while providing preferential accumulation at the target site. A number of nanocarriers have been developed; however, only a few of them are clinically approved for the delivery of antitumor drugs for their intended actions at the targeted sites. The present review is divided into three main parts: first part presents introduction of various nanocarriers and their relevance in the delivery of anticancer drugs, second part encompasses targeting mechanisms and surface functionalization on nanocarriers and third part covers the description of selected tumors, including breast, lungs, colorectal and pancreatic tumors, and applications of relative nanocarriers in these tumors. This review increases the understanding of tumor treatment with the promising use of nanotechnology. Dove Medical Press 2017-10-05 /pmc/articles/PMC5634382/ /pubmed/29042776 http://dx.doi.org/10.2147/IJN.S146315 Text en © 2017 Din et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Din, Fakhar ud
Aman, Waqar
Ullah, Izhar
Qureshi, Omer Salman
Mustapha, Omer
Shafique, Shumaila
Zeb, Alam
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_full Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_fullStr Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_full_unstemmed Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_short Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
title_sort effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634382/
https://www.ncbi.nlm.nih.gov/pubmed/29042776
http://dx.doi.org/10.2147/IJN.S146315
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