Cargando…
Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
High-intensity focused ultrasound (HIFU) is a promising and noninvasive treatment for solid tumors, which has been explored for potential clinical applications. However, the clinical applications of HIFU for large and deep tumors such as hepatocellular carcinoma (HCC) are severely limited by unsatis...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634388/ https://www.ncbi.nlm.nih.gov/pubmed/29042775 http://dx.doi.org/10.2147/IJN.S144058 |
_version_ | 1783270080602177536 |
---|---|
author | Zhang, Nan Wang, Ronghui Hao, Junnian Yang, Yang Zou, Hongmi Wang, Zhigang |
author_facet | Zhang, Nan Wang, Ronghui Hao, Junnian Yang, Yang Zou, Hongmi Wang, Zhigang |
author_sort | Zhang, Nan |
collection | PubMed |
description | High-intensity focused ultrasound (HIFU) is a promising and noninvasive treatment for solid tumors, which has been explored for potential clinical applications. However, the clinical applications of HIFU for large and deep tumors such as hepatocellular carcinoma (HCC) are severely limited by unsatisfactory imaging guidance, long therapeutic times, and damage to normal tissue around the tumor due to the high power applied. In this study, we developed doxorubicin/perfluorohexane-encapsulated hollow mesoporous Prussian blue nanoparticles (HMPBs-DOX/PFH) as theranostic agents, which can effectively guide HIFU therapy and enhance its therapeutic effects in combination with chemotherapy, by decreasing the cavitation threshold. We investigated the effects of this agent on ultrasound and magnetic resonance imaging in vitro and in vivo. In addition, we showed a highly efficient HIFU therapeutic effect against HCC tumors, as well as controlled drug release, owing to the phase-transitional performance of the PFH. We therefore conclude that HMPB-DOX/PFH is a safe and efficient nanoplatform, which holds significant promise for cancer theranostics against deep tumors in clinical settings. |
format | Online Article Text |
id | pubmed-5634388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-56343882017-10-17 Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors Zhang, Nan Wang, Ronghui Hao, Junnian Yang, Yang Zou, Hongmi Wang, Zhigang Int J Nanomedicine Original Research High-intensity focused ultrasound (HIFU) is a promising and noninvasive treatment for solid tumors, which has been explored for potential clinical applications. However, the clinical applications of HIFU for large and deep tumors such as hepatocellular carcinoma (HCC) are severely limited by unsatisfactory imaging guidance, long therapeutic times, and damage to normal tissue around the tumor due to the high power applied. In this study, we developed doxorubicin/perfluorohexane-encapsulated hollow mesoporous Prussian blue nanoparticles (HMPBs-DOX/PFH) as theranostic agents, which can effectively guide HIFU therapy and enhance its therapeutic effects in combination with chemotherapy, by decreasing the cavitation threshold. We investigated the effects of this agent on ultrasound and magnetic resonance imaging in vitro and in vivo. In addition, we showed a highly efficient HIFU therapeutic effect against HCC tumors, as well as controlled drug release, owing to the phase-transitional performance of the PFH. We therefore conclude that HMPB-DOX/PFH is a safe and efficient nanoplatform, which holds significant promise for cancer theranostics against deep tumors in clinical settings. Dove Medical Press 2017-10-05 /pmc/articles/PMC5634388/ /pubmed/29042775 http://dx.doi.org/10.2147/IJN.S144058 Text en © 2017 Zhang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zhang, Nan Wang, Ronghui Hao, Junnian Yang, Yang Zou, Hongmi Wang, Zhigang Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors |
title | Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors |
title_full | Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors |
title_fullStr | Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors |
title_full_unstemmed | Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors |
title_short | Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors |
title_sort | mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634388/ https://www.ncbi.nlm.nih.gov/pubmed/29042775 http://dx.doi.org/10.2147/IJN.S144058 |
work_keys_str_mv | AT zhangnan mesoporouscompositenanoparticlesfordualmodalityultrasoundmagneticresonanceimagingandsynergisticchemothermotherapyagainstdeeptumors AT wangronghui mesoporouscompositenanoparticlesfordualmodalityultrasoundmagneticresonanceimagingandsynergisticchemothermotherapyagainstdeeptumors AT haojunnian mesoporouscompositenanoparticlesfordualmodalityultrasoundmagneticresonanceimagingandsynergisticchemothermotherapyagainstdeeptumors AT yangyang mesoporouscompositenanoparticlesfordualmodalityultrasoundmagneticresonanceimagingandsynergisticchemothermotherapyagainstdeeptumors AT zouhongmi mesoporouscompositenanoparticlesfordualmodalityultrasoundmagneticresonanceimagingandsynergisticchemothermotherapyagainstdeeptumors AT wangzhigang mesoporouscompositenanoparticlesfordualmodalityultrasoundmagneticresonanceimagingandsynergisticchemothermotherapyagainstdeeptumors |