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Establishment of a repeated social defeat stress model in female mice
Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634448/ https://www.ncbi.nlm.nih.gov/pubmed/28993631 http://dx.doi.org/10.1038/s41598-017-12811-8 |
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author | Takahashi, Aki Chung, Jia-Ru Zhang, Song Zhang, Hongxing Grossman, Yael Aleyasin, Hossein Flanigan, Meghan E. Pfau, Madeline L. Menard, Caroline Dumitriu, Dani Hodes, Georgia E. McEwen, Bruce S. Nestler, Eric J. Han, Ming-Hu Russo, Scott J. |
author_facet | Takahashi, Aki Chung, Jia-Ru Zhang, Song Zhang, Hongxing Grossman, Yael Aleyasin, Hossein Flanigan, Meghan E. Pfau, Madeline L. Menard, Caroline Dumitriu, Dani Hodes, Georgia E. McEwen, Bruce S. Nestler, Eric J. Han, Ming-Hu Russo, Scott J. |
author_sort | Takahashi, Aki |
collection | PubMed |
description | Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). We demonstrate that females susceptible to RSDS display social avoidance, anxiety-like behavior, reduction of body weight, and elevated levels of circulating interleukin 6. In contrast, a subset of mice we term resilient only display anxiety-like behaviors after RSDS. This model allows for investigation of sex differences in the neurobiological mechanisms of defeat‒induced depression‒like behaviors. A robust female social defeat model is a critical first step in the identification and development of novel therapeutic compounds to treat depression and anxiety disorders in women. |
format | Online Article Text |
id | pubmed-5634448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56344482017-10-18 Establishment of a repeated social defeat stress model in female mice Takahashi, Aki Chung, Jia-Ru Zhang, Song Zhang, Hongxing Grossman, Yael Aleyasin, Hossein Flanigan, Meghan E. Pfau, Madeline L. Menard, Caroline Dumitriu, Dani Hodes, Georgia E. McEwen, Bruce S. Nestler, Eric J. Han, Ming-Hu Russo, Scott J. Sci Rep Article Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). We demonstrate that females susceptible to RSDS display social avoidance, anxiety-like behavior, reduction of body weight, and elevated levels of circulating interleukin 6. In contrast, a subset of mice we term resilient only display anxiety-like behaviors after RSDS. This model allows for investigation of sex differences in the neurobiological mechanisms of defeat‒induced depression‒like behaviors. A robust female social defeat model is a critical first step in the identification and development of novel therapeutic compounds to treat depression and anxiety disorders in women. Nature Publishing Group UK 2017-10-09 /pmc/articles/PMC5634448/ /pubmed/28993631 http://dx.doi.org/10.1038/s41598-017-12811-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Takahashi, Aki Chung, Jia-Ru Zhang, Song Zhang, Hongxing Grossman, Yael Aleyasin, Hossein Flanigan, Meghan E. Pfau, Madeline L. Menard, Caroline Dumitriu, Dani Hodes, Georgia E. McEwen, Bruce S. Nestler, Eric J. Han, Ming-Hu Russo, Scott J. Establishment of a repeated social defeat stress model in female mice |
title | Establishment of a repeated social defeat stress model in female mice |
title_full | Establishment of a repeated social defeat stress model in female mice |
title_fullStr | Establishment of a repeated social defeat stress model in female mice |
title_full_unstemmed | Establishment of a repeated social defeat stress model in female mice |
title_short | Establishment of a repeated social defeat stress model in female mice |
title_sort | establishment of a repeated social defeat stress model in female mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634448/ https://www.ncbi.nlm.nih.gov/pubmed/28993631 http://dx.doi.org/10.1038/s41598-017-12811-8 |
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