N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity

CX3CL1 (fractalkine) is a unique member of the CX3C chemokine family and mediates both adhesion and cell migration in inflammatory processes. Frequently, the activity of chemokines depends on a modified N-terminus as described for the N-terminus of CCL2 modified to a pGlu- (pyroglutamate) residue by...

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Detalles Bibliográficos
Autores principales: Kehlen, Astrid, Haegele, Monique, Böhme, Livia, Cynis, Holger, Hoffmann, Torsten, Demuth, Hans-Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634468/
https://www.ncbi.nlm.nih.gov/pubmed/28739588
http://dx.doi.org/10.1042/BSR20170712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634468/
https://www.ncbi.nlm.nih.gov/pubmed/28739588
http://dx.doi.org/10.1042/BSR20170712

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