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Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases

Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the characteristic genes of gan-shen Yin deficiency cons...

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Autores principales: Du, Juan, Zhong, Maofeng, Liu, Dong, Liang, Shufang, Liu, Xiaolin, Cheng, Binbin, Zhang, Yani, Yin, Zifei, Wang, Yuan, Ling, Changquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634572/
https://www.ncbi.nlm.nih.gov/pubmed/29234393
http://dx.doi.org/10.1155/2017/4109828
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author Du, Juan
Zhong, Maofeng
Liu, Dong
Liang, Shufang
Liu, Xiaolin
Cheng, Binbin
Zhang, Yani
Yin, Zifei
Wang, Yuan
Ling, Changquan
author_facet Du, Juan
Zhong, Maofeng
Liu, Dong
Liang, Shufang
Liu, Xiaolin
Cheng, Binbin
Zhang, Yani
Yin, Zifei
Wang, Yuan
Ling, Changquan
author_sort Du, Juan
collection PubMed
description Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases. Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients. The mRNA expressions of 17 genes in PLC patients with gan-shen Yin deficiency were different from those without gan-shen Yin deficiency. However, considering all patients with PLC, HBP, and DM, only MLH3 was significantly lower in gan-shen Yin deficiency group than that in non-gen-shen Yin deficiency. By ROC analysis, the relationship between MLH3 and gan-shen Yin deficiency constitution was confirmed. Treatment of MLH3 (−/− and −/+) mice with Liuweidihuang wan, classical prescriptions for Yin deficiency, partly ameliorates the body constitution of Yin deficiency in MLH3 (−/+) mice, but not in MLH3 (−/−) mice. MLH3 might be one of material bases of gan-shen Yin deficiency constitution.
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spelling pubmed-56345722017-12-11 Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases Du, Juan Zhong, Maofeng Liu, Dong Liang, Shufang Liu, Xiaolin Cheng, Binbin Zhang, Yani Yin, Zifei Wang, Yuan Ling, Changquan Evid Based Complement Alternat Med Research Article Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases. Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients. The mRNA expressions of 17 genes in PLC patients with gan-shen Yin deficiency were different from those without gan-shen Yin deficiency. However, considering all patients with PLC, HBP, and DM, only MLH3 was significantly lower in gan-shen Yin deficiency group than that in non-gen-shen Yin deficiency. By ROC analysis, the relationship between MLH3 and gan-shen Yin deficiency constitution was confirmed. Treatment of MLH3 (−/− and −/+) mice with Liuweidihuang wan, classical prescriptions for Yin deficiency, partly ameliorates the body constitution of Yin deficiency in MLH3 (−/+) mice, but not in MLH3 (−/−) mice. MLH3 might be one of material bases of gan-shen Yin deficiency constitution. Hindawi 2017 2017-09-26 /pmc/articles/PMC5634572/ /pubmed/29234393 http://dx.doi.org/10.1155/2017/4109828 Text en Copyright © 2017 Juan Du et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Du, Juan
Zhong, Maofeng
Liu, Dong
Liang, Shufang
Liu, Xiaolin
Cheng, Binbin
Zhang, Yani
Yin, Zifei
Wang, Yuan
Ling, Changquan
Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases
title Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases
title_full Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases
title_fullStr Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases
title_full_unstemmed Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases
title_short Reduced MLH3 Expression in the Syndrome of Gan-Shen Yin Deficiency in Patients with Different Diseases
title_sort reduced mlh3 expression in the syndrome of gan-shen yin deficiency in patients with different diseases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634572/
https://www.ncbi.nlm.nih.gov/pubmed/29234393
http://dx.doi.org/10.1155/2017/4109828
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