Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relat...

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Detalles Bibliográficos
Autores principales: Ma, Pengfei, Fu, Yujie, Cai, Mei-Chun, Yan, Ying, Jing, Ying, Zhang, Shengzhe, Chen, Minjiang, Wu, Jie, Shen, Ying, Zhu, Liang, Chen, Hong-Zhuan, Gao, Wei-Qiang, Wang, Mengzhao, Gu, Zhenyu, Bivona, Trever G., Zhao, Xiaojing, Zhuang, Guanglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634994/
https://www.ncbi.nlm.nih.gov/pubmed/29018192
http://dx.doi.org/10.1038/s41467-017-00963-0

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